Jan 14, 2020

Early postoperative statin administration does not affect the rate of atrial fibrillation after cardiac surgery

European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
Jahangir KhanKati M Järvelä

Abstract

Postoperative atrial fibrillation is the most frequent complication after cardiac surgery, and the use of statins in preventing them is being extensively studied. The aim of this study was to investigate whether a pause in the administration of statins affects the occurrence of atrial fibrillation after cardiac surgery in a prospective randomized and controlled setting. A total of 301 patients without chronic atrial fibrillation with prior statin medication scheduled for elective or urgent cardiac surgery involving the coronary arteries and/or heart valves were prospectively recruited and randomized for statin re-initiation on either the first (immediate statin group) or the fifth (late statin group) postoperative day, using the original medication and dosage. The immediate statin group comprised 146 patients and the late statin group 155 patients. Except for a somewhat higher rate of males (85% vs 73%, P = 0.016) in the immediate statin group, the baseline characteristics and the distribution of procedures performed within the groups were comparable. The occurrence of postoperative atrial fibrillation and the clinical course of the patients were compared between the groups. The incidence of atrial fibrillation was 46% and the ...Continue Reading

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Mentioned in this Paper

Cardiac Surgery Procedures
Observation Parameter
Randomization
Administration Procedure
Operative Surgical Procedures
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Chronic Atrial Fibrillation
EEF1A2
Study
Explanation of Plan: Medication

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