Early posttransplant lymphoproliferative disease in pediatric liver transplant recipients

Transplantation Proceedings
J RoqueJ Hepp

Abstract

Among 23 pediatric patients who underwent orthotopic liver transplant (OLT), we report two (11 and 26 months old) with posttransplant lymphoproliferative disease (PTLD) that occurred in the early posttransplantation period. They were Epstein-Barr Virus (EBV)-negative and received graft from EBV-positive donors. The surveillance for EBV viremia using serial EBV polymerase chain reaction determinations in the peripheral blood was positive at 10 and 90 days after OLT concomitant with symptoms of primary infection, both patients were treated with gancyclovir. The patients should progression to a Burkitt's and a non-Hodgkin's lymphoma that appeared 3 months posttransplantation. They were treated by withdrawal of immunosuppression and six courses of cyclophosphamide as well as anti-CD20 monoclonal antibody (Rituximab) every 21 days. One patient experienced acute graft rejection, which resolved with steroids and low doses of tacrolimus, she is free of disease at 24 months after the end of treatment. The other patient relapsed with a cerebral lymphoma, receiving aggressive chemotherapy, but died due to sepsis. In conclusion, PTLD occurred among in 2/23 patients who underwent OLT and appeared in the first quarter post OLT. The risk fact...Continue Reading

Citations

May 13, 2008·Gastroenterology·Mike A Leonis, William F Balistreri
May 26, 2007·Transplantation Proceedings·A N HaberalM Haberal
Jul 26, 2012·Hematology/oncology and Stem Cell Therapy·Hossein Khedmat, Saeed Taheri
Jan 26, 2010·International Journal of Pharmaceutics·Ales BelicFranc Vrecer
Jun 21, 2013·Progress in Transplantation : Official Publication, North American Transplant Coordinators Organization ... [et Al.]·Hossein KhedmatSaeed Taheri
Dec 12, 2012·International Journal of Surgical Pathology·Carlos E BenítezJosé R Valbuena
May 28, 2019·BJR Case Reports·James Anthony KorfTheodore C Schultheiss

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