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Early preclinical detection of prions in the skin of prion-infected animals

Nature Communications

Jan 16, 2019

Zerui WangWen-Quan Zou

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Abstract

A definitive pre-mortem diagnosis of prion disease depends on brain biopsy for prion detection currently and no validated alternative preclinical diagnostic tests have been reported to date. To determine the feasibility of using skin for preclinical diagnosis, here we report ultrasensit...read more

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Monoclonal Antibodies
Biological Markers
Brain
Hamsters
Mesocricetus
Laboratory mice
Mice, Transgenic
Scrapie
Vaccination
PrPSc Proteins
16
8
16
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Early preclinical detection of prions in the skin of prion-infected animals

Nature Communications

Jan 16, 2019

Zerui WangWen-Quan Zou

PMID: 30651538

DOI: 10.1038/s41467-018-08130-9

Abstract

A definitive pre-mortem diagnosis of prion disease depends on brain biopsy for prion detection currently and no validated alternative preclinical diagnostic tests have been reported to date. To determine the feasibility of using skin for preclinical diagnosis, here we report ultrasensit...read more

Mentioned in this Paper

Monoclonal Antibodies
Biological Markers
Brain
Hamsters
Mesocricetus
16
8
16

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