Early Prediction Model for Successful Bridge to Recovery in Patients With Fulminant Myocarditis Supported With Percutaneous Venoarterial Extracorporeal Membrane Oxygenation - Insights From the CHANGE PUMP Study

Circulation Journal : Official Journal of the Japanese Circulation Society
Akinori SawamuraCHANGE PUMP Investigators

Abstract

Cardiac recovery and prevention of end-organ damage are the cornerstones of establishing successful bridge to recovery (BTR) in patients with fulminant myocarditis (FM) supported with percutaneous venoarterial extracorporeal membrane oxygenation (VA-ECMO). However, the timing and method of successful BTR prediction still remain unclear. We aimed to develop a prediction model for successful BTR in patients with FM supported with percutaneous VA-ECMO.Methods and Results:This was a retrospective multicenter chart review enrolling 99 patients (52±16 years; female, 42%) with FM treated with percutaneous VA-ECMO. The S-group comprised patients who experienced percutaneous VA-ECMO decannulation and subsequent discharge (n=46), and the F-group comprised patients who either died in hospital or required conversion to other forms of mechanical circulatory support (n=53). At VA-ECMO initiation (0-h), the S-group had significantly higher left ventricular ejection fraction (LVEF) and lower aspartate aminotransferase (AST) concentration than the F-group. At 48 h, the LVEF, increase in the LVEF, and reduction of AST from 0-h were identified as independent predictors in the S-group. Finally, we developed an S-group prediction model comprising t...Continue Reading

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Citations

Mar 13, 2018·Current Opinion in Cardiology·Jonathan Buggey, Chantal A ElAmm
Nov 7, 2019·Pathology International·Kyoko Imanaka-Yoshida
Jun 5, 2018·Circulation Journal : Official Journal of the Japanese Circulation Society·Akinori SawamuraUNKNOWN CHANGE PUMP Investigators
Oct 31, 2020·International Journal of Cardiology·Giacomo VeroneseDao Wen Wang
Jun 11, 2021·The Journal of Emergency Medicine·Michael GottliebBrit Long
Jun 27, 2021·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Naoki TadokoroTomoyuki Fujita
Jul 27, 2021·Frontiers in Cardiovascular Medicine·Adamantios TsangarisDemetris Yannopoulos

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