Early prediction of changes in weight during six weeks of treatment with antidepressants

Journal of Psychiatric Research
Hubertus HimmerichThomas Pollmächer

Abstract

Weight gain is a frequent and important side effect of psychotropic treatment. We sought to determine weight change predictors during treatment with antidepressant drugs. In 24 patients weight, plasma levels of leptin, tumor necrosis factor-alpha (TNF-alpha and soluble TNF receptors were determined longitudinally and a multiple linear regression analysis was used to predict weight change from baseline to the sixth week of treatment. Changes of weight during the first week of treatment, but no other parameter, strongly predicted weight change until endpoint (adjusted R2 = 0.68, F = 50.45, df = 1,23, p < 0.001). Very early changes in weight during treatment with psychotropic drugs might be a simple and clinically useful predictor of future weight development.

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Citations

Nov 11, 2009·Der Nervenarzt·T Veselinović, H Himmerich
Mar 29, 2008·Metabolic Syndrome and Related Disorders·Trino BaptistaMaritza Martinez
May 29, 2009·International Clinical Psychopharmacology·Anna SecherErling Mellerup
Sep 6, 2011·The Australian and New Zealand Journal of Psychiatry·Seetal DoddMichael Berk
Sep 11, 2014·Der Nervenarzt·H HimmerichC Rummel-Kluge
Aug 31, 2007·Molecular and Cellular Neurosciences·Yechiel LevkovitzYehiel Zick
Aug 16, 2016·The Psychiatric Clinics of North America·Joseph F Goldberg, Carrie L Ernst
Oct 3, 2006·Pharmacology & Therapeutics·Sharon Rosenzweig-LipsonLee E Schechter
Aug 30, 2008·JPEN. Journal of Parenteral and Enteral Nutrition·Gordon L Jensen
Oct 13, 2017·Journal of the American Association of Nurse Practitioners·Mary Madeline Rogge, Bibha Gautam
Nov 27, 2004·Psychopharmacology·Hubertus HimmerichThomas Pollmächer

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