Early prediction of COVID-19 severity using extracellular vesicle COPB2.

Journal of Extracellular Vesicles
Yu FujitaTakahiro Ochiya

Abstract

The clinical manifestations of COVID-19 vary broadly, ranging from asymptomatic infection to acute respiratory failure and death. But the predictive biomarkers for characterizing the variability are still lacking. Since emerging evidence indicates that extracellular vesicles (EVs) and extracellular RNAs (exRNAs) are functionally involved in a number of pathological processes, we hypothesize that these extracellular components may be key determinants and/or predictors of COVID-19 severity. To test our hypothesis, we collected serum samples from 31 patients with mild COVID-19 symptoms at the time of their admission for discovery cohort. After symptomatic treatment without corticosteroids, 9 of the 31 patients developed severe/critical COVID-19 symptoms. We analyzed EV protein and exRNA profiles to look for correlations between these profiles and COVID-19 severity. Strikingly, we identified three distinct groups of markers (antiviral response-related EV proteins, coagulation-related markers, and liver damage-related exRNAs) with the potential to serve as early predictive biomarkers for COVID-19 severity. As the best predictive marker, EV COPB2 protein, a subunit of the Golgi coatomer complex, exhibited significantly higher abundan...Continue Reading

References

Jul 28, 2009·FEBS Letters·R BeckD Cassel
Mar 23, 2010·Proceedings of the National Academy of Sciences of the United States of America·D Michiel PegtelJaap M Middeldorp
Aug 24, 2010·Neurochemical Research·Hyo Sang JangJeffrey A Greenwood
Jul 5, 2011·Cell Metabolism·Carlos I MichelJean E Schaffer
Oct 21, 2011·Physiology·Tomasz Szul, Elizabeth Sztul
Jun 12, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Shashi BalaGyongyi Szabo
Feb 16, 2013·Nature Reviews. Microbiology·Benjamin R tenOever
Feb 26, 2014·Nature Reviews. Immunology·Paul D Robbins, Adrian E Morelli
May 17, 2015·Journal of Extracellular Vesicles·María Yáñez-MóOlivier De Wever
Feb 10, 2016·Proceedings of the National Academy of Sciences of the United States of America·Joanna KowalClotilde Théry
Nov 10, 2017·American Journal of Physiology. Endocrinology and Metabolism·Anu Alice ThomasSubrata Chakrabarti
Jul 8, 2018·The Journal of Biological Chemistry·Jamie M RimerJean E Schaffer
Oct 20, 2018·Frontiers in Genetics·Erika GirardiSébastien Pfeffer
Feb 28, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Fumihiko UrabeTakahiro Ochiya
Feb 23, 2020·The Lancet Infectious Diseases·Ensheng DongLauren Gardner
Feb 29, 2020·The New England Journal of Medicine·Wei-Jie GuanUNKNOWN China Medical Treatment Expert Group for Covid-19
Mar 8, 2020·The Lancet. Gastroenterology & Hepatology·Chao ZhangFu-Sheng Wang
Mar 17, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Pingzheng MoYongxi Zhang
Mar 17, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Zhongliang WangRuiguang Zhang
Mar 24, 2020·Laboratory Investigation; a Journal of Technical Methods and Pathology·Sophie Sarah SteinhaeuserThorarinn Gudjonsson
Apr 17, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jiao GongBo Hu
May 15, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·John J Y ZhangBarnaby Edward Young
May 27, 2020·Open Forum Infectious Diseases·Guyi WangYanjun Zhong
Jun 23, 2020·Annals of Translational Medicine·Daozheng HuangShouhong Wang
Jul 2, 2020·Immunity·Nilam Mangalmurti, Christopher A Hunter

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