Early prediction of intestinal mucosal barrier function impairment by elevated serum procalcitonin in rats with severe acute pancreatitis

Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
Hong-chang LiDian-xu Feng

Abstract

The aim of this study was to evaluate serum procalcitonin (PCT) levels as a prognostic indicator of intestinal barrier function impairment in rats with severe acute pancreatitis (SAP). Thirty-six male Sprague Dawley rats were randomly grouped into SAP group (injected sodium taurocholate via biliopancreatic duct), Gln group (gavaged with glutamine after modeling), and control group. Blood, pancreatic, and terminal ileum tissues were obtained from the rats after 6 h of modeling. Serum amylase (Amy) levels were determined using an automatic biochemical detector, while endotoxin (ET), diamine oxidase (DAO), and PCT levels were measured by ELISA test. The pathology of pancreatic and small intestine tissues were observed. PCT protein expression in intestinal tissues were detected by immunohistochemistry and western blot. Pancreatic and intestinal injuries in Gln group were significantly lower than SAP group. Serum amylase, DAO, and PCT levels in SAP and Gln groups differed greatly and were significantly higher than control group. Immuno-histochemistry and western blot results showed that PCT protein expression levels in small intestine tissues of SAP group were higher than Gln group and control group. Serum PCT levels had a significa...Continue Reading

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Citations

Oct 17, 2018·Canadian Journal of Physiology and Pharmacology·Hua-Li HuangHe-Ping Qin
Jun 15, 2017·World Journal of Gastroenterology : WJG·Jun LiZong-Fang Li
Feb 24, 2021·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Yu ZhangLingmin Zhou
Mar 2, 2021·World Journal of Gastroenterology : WJG·Ya-Mei ZhengLi-Hao Wu

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