Early prediction of lenvatinib treatment efficacy by using 18 F-FDG PET/CT in patients with unresectable or advanced thyroid carcinoma that is refractory to radioiodine treatment: a protocol for a non-randomized single-arm multicenter observational study

BMJ Open
Satoshi TakeuchiHirotoshi Dosaka-Akita

Abstract

Lenvatinib, an oral molecular targeted drug, is used to treat patients with unresectable or advanced thyroid carcinoma that is refractory to radioiodine treatment. Effective methods for evaluating molecular targeted drugs are a critical unmet need owing to their expensive costs and unique adverse events. The aim of this study is to determine whether 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT at 1 week after commencing lenvatinib can predict treatment outcomes. This study is planned as a non-randomised single-arm multicentre study; patients with pathologically confirmed differentiated thyroid carcinoma (DTC) with lesions that are refractory to radioiodine treatment are eligible. The main exclusion criteria are medullary or anaplastic carcinoma, prior treatment with chemotherapy, poor general condition and thromboembolism-requiring treatment. Patients to be included in the study will be treated with lenvatinib and undergo FDG-PET/CT examination twice: before and 1 week after the initiation of treatment. Contrast-enhanced CT, the gold standard for evaluation, will be performed at least 4 weeks after the initiation of treatment. The primary objective is to evaluate the ability of the lesion maximum standard ...Continue Reading

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Citations

Mar 23, 2019·Reviews in Endocrine & Metabolic Disorders·Arnoldo PiccardoLuca Giovanella
Mar 25, 2019·Archives of Disease in Childhood·Hugh T DaviesSimon R Stones
Dec 18, 2019·Heart·Neil Ruparelia, Robin Choudhury
Apr 25, 2019·BMJ Quality & Safety·Halley Ruppel, Vincent Liu
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Apr 10, 2019·Experimental Biology and Medicine·Ajaikumar B KunnumakkaraBharat B Aggarwal
Feb 20, 2021·Nature Reviews. Endocrinology·Matti L GildBruce G Robinson

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