Early prediction of outcome in score-identified, postcardiac surgical patients at high risk for sepsis, using soluble tumor necrosis factor receptor-p55 concentrations

Critical Care Medicine
G PilzD Seidel

Abstract

To investigate the prognostic value of increased serum concentrations of soluble tumor necrosis factor (TNF) receptors in patients at high risk for sepsis. Prospective study. Cardiac surgical intensive care unit in a University Hospital. Those 27 of 870 consecutive postcardiac surgical patients who met a previously validated high-risk criterion for imminent sepsis (Acute Physiology and Chronic Health Evaluation II [APACHE II] score of > or = 24 on the first postoperative day [day 1]). In this population, systemic inflammatory response syndrome was present in 96% of the patients and the in-hospital mortality rate was 30%. In addition, ten postcardiac surgical patients with an uncomplicated course (mortality rate 0%) were studied for comparison. Blood sampling for measurements of serum concentrations of TNF and soluble TNF receptors 55 kilodalton (TNF receptor-p55) and 75 kilodalton (TNF receptor-p75) on days 1, 2, 3, and 5. Compared with the ten patients with an uncomplicated course (group A), the high-risk patients had significantly higher baseline (day 1) serum concentrations of soluble TNF receptor-p55 (9.2 vs. 4.2 ng/mL) and soluble TNF receptor-p75 (9.2 vs. 5.5 ng/mL). These high-risk patients could be further differentiate...Continue Reading

References

Oct 1, 1992·The Annals of Thoracic Surgery·N J JansenC R Wildevuur
Nov 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·T KohnoJ L Vannice
Mar 1, 1989·European Journal of Haematology·I OlssonG Adolf
Oct 1, 1985·Critical Care Medicine·W A KnausJ E Zimmerman
Jan 1, 1983·The British Journal of Surgery·E A Elebute, H B Stoner
Nov 1, 1994·Intensive Care Medicine·I Durand-Zaleski
Oct 1, 1993·The Journal of Infectious Diseases·T van der PollS J van Deventer
Jan 1, 1950·Cancer·W J YOUDEN

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Citations

Oct 1, 1996·Molecular and Cellular Biochemistry·K Werdan, U Müller-Werdan
Sep 22, 2005·Der Unfallchirurg·F HildebrandC Krettek
Oct 18, 2003·Cytokine & Growth Factor Reviews·Richard B GoodmanMichael A Matthay
May 17, 2001·Journal of Gastroenterology and Hepatology·F KimuraH Yoshitome
May 17, 2001·Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis·K Werdan
Dec 13, 2007·Critical Care Medicine·Karl WerdanUNKNOWN Score-Based Immunoglobulin Therapy of Sepsis (SBITS) Study Group
Dec 20, 2007·Critical Care Medicine·Karl WerdanUNKNOWN Early Supplemental Severe SIRS Treatment With IVIG in Score-Identified High-Risk Patients After Cardiac Surgery (ESSICS) Stu
Jun 3, 1999·Clinical Chemistry and Laboratory Medicine : CCLM·K Werdan
Apr 28, 2005·The Annals of Thoracic Surgery·Khosro HekmatUwe Mehlhorn
Apr 12, 2005·The Journal of Thoracic and Cardiovascular Surgery·Roland ProndzinskyKarl Werdan
Jan 30, 2003·The British Journal of Surgery·R W ParksB J Rowlands
Oct 29, 2008·Clinics in Chest Medicine·Corey E Ventetuolo, Mitchell M Levy
Mar 29, 2000·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·C KuhnK Werdan
Apr 27, 2002·Heart Disease·A S Retter, W H Frishman
Jul 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marcin F OsuchowskiDaniel G Remick
Apr 13, 1999·The American Journal of Physiology·G L CarlsonM H Irving

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