Early prediction of sepsis-induced disseminated intravascular coagulation with interleukin-10, interleukin-6, and RANTES in preterm infants

Clinical Chemistry
Pak C NgTai F Fok

Abstract

The progression to disseminated intravascular coagulation (DIC) in infected very low birth weight (VLBW; <1500 g) infants is difficult to predict with precision at the onset of sepsis. We investigated the immunologic profiles of preterm infants with sepsis, using chemokine and cytokine measurements to predict the development of sepsis-induced DIC at the onset of infection. We measured a panel of chemokines and cytokines at 0 and 24 h after clinical presentation in VLBW infants with suspected infection requiring full sepsis screening. The chemokines measured were interleukin (IL)-8, interferon-gamma-inducible protein-10 (IP-10), monokine induced by interferon-gamma, monocyte chemoattractant protein-1, and regulated upon activation normal T-cell expressed and secreted (RANTES), and the cytokines were IL-6, IL-10, and tumor necrosis factor-alpha. Of 195 episodes of suspected clinical sepsis investigated, 62 were culture-confirmed septicemia or necrotizing enterocolitis (28 of these infants developed DIC), 22 were culture-negative clinical infections, and 111 involved noninfected episodes. All studied inflammatory mediators except RANTES showed significantly greater up-regulation in culture-positive infected infants than in noninfe...Continue Reading

References

Jul 1, 1992·Infection and Immunity·C E HackL A Aarden
Jan 1, 1988·Pediatrics in Review·M C WalshA A Fanaroff
Feb 12, 1998·The New England Journal of Medicine·A D Luster
Feb 14, 1998·Archives of Disease in Childhood. Fetal and Neonatal Edition·P C NgK L Cheung
Sep 12, 1998·Lancet·J T van DisselM Frölich
Jan 14, 2000·Journal of Clinical Immunology·D P OlszynaT Van Der Poll
Jun 3, 2000·Annual Review of Immunology·D Rossi, A Zlotnik
Mar 10, 2001·Cytokine·O DammannUNKNOWN ELGAN STUDY INVESTIGATORS
Apr 5, 2001·Trends in Immunology·V Appay, S L Rowland-Jones
Jun 26, 2001·European Journal of Pediatrics·C RomagnoliG Tortorolo
Apr 30, 2002·Pediatric Research·Sandra E SullivanDarlene A Calhoun
Apr 30, 2003·Archives of Disease in Childhood. Fetal and Neonatal Edition·P C NgT F Fok
Nov 19, 2003·Scandinavian Journal of Infectious Diseases·Jean-Marc CavaillonDidier Payen
Dec 18, 2003·Clinical and Experimental Immunology·C SchultzC Härtel
Feb 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Silvio DaneseClaudio Fiocchi
Apr 23, 2004·Archives of Disease in Childhood. Fetal and Neonatal Edition·P C Ng
Nov 18, 2004·JAMA : the Journal of the American Medical Association·Barbara J StollUNKNOWN National Institute of Child Health and Human Development Neonatal Research Network
Feb 3, 2005·The Journal of Infectious Diseases·Anne-Sophie W MøllerPeter Kierulf

❮ Previous
Next ❯

Citations

Oct 2, 2013·Seminars in Fetal & Neonatal Medicine·Pak Cheung Ng
Dec 24, 2013·BMC Research Notes·Setyadewi LusyatiPieter J J Sauer
Jun 1, 2007·Biomarkers in Medicine·Hugh S Lam, Pak C Ng
Oct 23, 2009·Journal of Perinatology : Official Journal of the California Perinatal Association·B Shouman, R Badr
Sep 17, 2009·Pediatric Research·Girija NatarajanUNKNOWN NICHD neonatal research network
Jan 15, 2010·The Journal of Experimental Medicine·Kindra M Kelly-ScumpiaLyle L Moldawer
Jul 9, 2010·Pediatric Research·Rupak MukherjeeFrancis G Spinale
Aug 31, 2010·Clinical Chemistry·Paul E OranRandall W Nelson
Oct 28, 2008·Journal of Tropical Pediatrics·Hsiu-Lin ChenRei-Cheng Yang
Mar 31, 2011·Journal of Tropical Pediatrics·Hsiu-Lin ChenRei-Cheng Yang
Sep 10, 2013·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·V SugithariniE Berla Thangam
Nov 15, 2006·European Journal of Pediatrics·Kosmas SarafidisFlorence Kanakoudi-Tsakalidou
Dec 3, 2009·The Kaohsiung Journal of Medical Sciences·Hsiu-Lin ChenRei-Cheng Yang
Feb 19, 2013·Clinics in Perinatology·Pak C NgTerence C W Poon
Nov 21, 2012·Seminars in Fetal & Neonatal Medicine·M MussapV Fanos
Dec 18, 2010·The Journal of Arthroplasty·Arjun SaxenaJavad Parvizi
Sep 4, 2010·Clinics in Perinatology·Pak C Ng, Hugh S Lam
Jun 24, 2010·Clinics in Perinatology·James L Wynn, Hector R Wong
Jun 9, 2009·Veterinary Immunology and Immunopathology·A B BurtonD M Ainsworth
Feb 11, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Joris R Delanghe, Marijn M Speeckaert
Oct 25, 2008·BJOG : an International Journal of Obstetrics and Gynaecology·C S BuhimschiI A Buhimschi
Oct 19, 2011·Acta Paediatrica·Sofia Ygberg, Anna Nilsson
Jan 19, 2008·Pathology·Hugh S Lam, Pak C Ng
Jan 4, 2015·Archives of Disease in Childhood. Fetal and Neonatal Edition·Pak Cheung NgHugh Simon Lam
Apr 23, 2014·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Turan TuncSultan Kavuncuoglu
Sep 14, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Michele Mussap
Aug 6, 2010·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Antonia ManouraChristine Giannakopoulou
Jun 25, 2016·Expert Reviews in Molecular Medicine·Steven X ChoMarcel F Nold
Sep 7, 2016·Stem Cells and Development·Kam Tong LeungPak Cheung Ng
Oct 1, 2014·Inflammatory Bowel Diseases·Hendrik J NiemarktNanne K H de Boer
Jul 5, 2012·Neonatology·Pak C Ng, Hugh S Lam
May 9, 2012·Pediatric Research·Beena G SoodUNKNOWN Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
Mar 2, 2018·Pediatrics International : Official Journal of the Japan Pediatric Society·Wael Seliem, Amira M Sultan
Dec 21, 2007·The Korean journal of laboratory medicine·Ji Weon SeoHan Ik Cho
May 2, 2008·Current Opinion in Infectious Diseases·Shmuel Arnon, Ita Litmanovitz
Mar 25, 2009·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Ana Carolina CancelierFelipe Dal-Pizzol
Feb 3, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Selma CetinDavid J Hackam
May 10, 2020·Pediatric Research·Leeann R PavlekLynette K Rogers
May 15, 2020·PloS One·Julie HibbertAndrew Currie
Jul 2, 2010·The Journal of Clinical Investigation·Pak Cheung NgTerence Chuen Wai Poon
Feb 22, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Barbara Królak-Olejnik, Igor Olejnik

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.