Early predictors of clinical outcomes of COVID-19 outbreak in Milan, Italy

Clinical Immunology : the Official Journal of the Clinical Immunology Society
Fabio CiceriAlberto Zangrillo

Abstract

National health-system hospitals of Lombardy faced a heavy burden of admissions for acute respiratory distress syndromes associated with coronavirus disease (COVID-19). Data on patients of European origin affected by COVID-19 are limited. All consecutive patients aged ≥18 years, coming from North-East of Milan's province and admitted at San Raffaele Hospital with COVID-19, between February 25th and March 24th, were reported, all patients were followed for at least one month. Clinical and radiological features at admission and predictors of clinical outcomes were evaluated. Of the 500 patients admitted to the Emergency Unit, 410 patients were hospitalized and analyzed: median age was 65 (IQR 56-75) years, and the majority of patients were males (72.9%). Median (IQR) days from COVID-19 symptoms onset was 8 (5-11) days. At hospital admission, fever (≥ 37.5 °C) was present in 67.5% of patients. Median oxygen saturation (SpO2) was 93% (range 60-99), with median PaO2/FiO2 ratio, 267 (IQR 184-314). Median Radiographic Assessment of Lung Edema (RALE) score was 9 (IQR 4-16). More than half of the patients (56.3%) had comorbidities, with hypertension, coronary heart disease, diabetes and chronic kidney failure being the most common. The ...Continue Reading

Associated Clinical Trials

References

Jan 16, 2008·Radiology·David M HansellJacques Remy
Dec 15, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A G DullooY Schutz
Mar 10, 2019·Critical Care : the Official Journal of the Critical Care Forum·Audrey De JongSamir Jaber
Mar 16, 2019·Nature Reviews. Disease Primers·Michael A MatthayCarolyn S Calfee
Jan 30, 2020·The New England Journal of Medicine·Qun LiZijian Feng
Feb 29, 2020·The New England Journal of Medicine·Wei-Jie GuanUNKNOWN China Medical Treatment Expert Group for Covid-19
Mar 24, 2020·Cellular & Molecular Immunology·Meijuan ZhengZhigang Tian
Apr 1, 2020·The Lancet Infectious Diseases·Francois-Xavier LescureYazdan Yazdanpanah
Apr 14, 2020·JAMA : the Journal of the American Medical Association·James M SandersJames B Cutrell
Apr 23, 2020·JAMA : the Journal of the American Medical Association·Safiya RichardsonTheodoros P Zanos
Apr 23, 2020·Cell Host & Microbe·Evangelos J Giamarellos-BourboulisAntonia Koutsoukou
Apr 25, 2020·Nature Reviews. Immunology·Antonio M RisitanoJohn D Lambris
May 4, 2020·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Sara MastaglioFabio Ciceri

❮ Previous
Next ❯

Citations

Sep 1, 2020·Acta Diabetologica·Giuseppe PuglieseEmanuela Orsi
Aug 29, 2020·Annals of the Rheumatic Diseases·Emanuel Della-TorreMoreno Tresoldi
Sep 8, 2020·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Hai HuYanru Qiu
Aug 28, 2020·Reviews in Medical Virology·Benjamin Gallo MarinIan C Michelow
Jun 26, 2020·Pathogens and Global Health·Fabio CiceriUNKNOWN COVID-BioB Study Group
Aug 14, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Christiane Maria Prado JeronimoUNKNOWN Metcovid Team
Oct 16, 2020·PloS One·Alejandro Rodríguez-MolineroUNKNOWN COVID-19 Research Group of CSAPG
Nov 3, 2020·Cell Biochemistry and Function·Davide FerrariGiovanni Lombardi
Aug 3, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Elizabeth C VernaK Rajender Reddy
Sep 30, 2020·The Journal of Clinical Investigation·Massimiliano SecchiVito Lampasona
Nov 25, 2020·ESC Heart Failure·Sarah J CharmanDjordje G Jakovljevic
Nov 18, 2020·Journal of Medical Virology·Jun YangJiahao Li
Oct 11, 2020·Journal of Clinical Medicine·Gregory MansellaChristian H Nickel
Dec 3, 2020·Frontiers in Medicine·Maximilian KoblischkeJudith H Aberle
Dec 18, 2020·Frontiers in Immunology·Sabina CenciarelliFrancesca Ferrua
Jan 8, 2021·Scandinavian Journal of Public Health·Morten Hulvej Rod, Naja Hulvej Rod
Dec 18, 2020·Current Opinion in Rheumatology·Yu LiuQianjin Lu
Sep 25, 2020·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Kamal S SainiEvandro de Azambuja
Dec 15, 2020·Infectious Diseases·Maria AbbattistaIda Martinelli
Feb 9, 2021·Journal of Perinatal Medicine·Amos GrünebaumPhilip A Mackowiak
Feb 2, 2021·Journal of Cardiothoracic and Vascular Anesthesia·Francesco De CobelliAlberto Zangrillo
Sep 21, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Antonella d'Arminio MonforteGiulia Marchetti
Feb 14, 2021·Cancers·Fahriye DuzagacFlavio Rizzolio
Jan 30, 2021·The Journal of Clinical Endocrinology and Metabolism·Stefania DispinseriLorenzo Piemonti
Nov 24, 2020·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Marco RipaUNKNOWN COVID-BioB study group
Mar 7, 2021·Journal of Personalized Medicine·Deborah TraversiStefania Boccia
Feb 21, 2021·Biomedical Journal·Paola MagroEugenia Quiros-Roldan
Feb 27, 2021·Medicina clínica·Chendi LiangGang Qin
Mar 4, 2021·Acta Anaesthesiologica Scandinavica·Giacomo MontiAlberto Zangrillo
Mar 21, 2021·Diabetes Research and Clinical Practice·Ilhan SatmanAlper Sonmez

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray

Clinical Trials Mentioned

NCT04318366

Software Mentioned

R
SAS
qXR
SPSS
AI

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.