Early predictors of mortality from Pneumocystis jirovecii pneumonia in HIV-infected patients: 1985-2006

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
P D WalzerRobert F Miller

Abstract

Pneumocystis jirovecii pneumonia (PCP) remains the leading cause of opportunistic infection among human immunodeficiency virus (HIV)-infected persons. Previous studies of PCP that identified case-fatality risk factors involved small numbers of patients, were performed over few years, and often focused on patients who were admitted to the intensive care unit. The objective of this study was to identify case-fatality risk factors present at or soon after hospitalization among adult HIV-infected patients admitted to University College London Hospitals (London, United Kingdom) from June 1985 through June 2006. We performed a review of case notes for 494 consecutive patients with 547 episodes of laboratory-confirmed PCP. Overall mortality was 13.5%. Mortality was 10.1% for the period from 1985 through 1989, 16.9% for the period from 1990 through June 1996, and 9.7% for the period from July 1996 through 2006 (P = .142). Multivariate analysis identified factors associated with risk of death, including increasing patient age (adjusted odds ratio [AOR], 1.54; 95% confidence interval [CI], 1.11-2.23; P = .011), subsequent episode of PCP (AOR, 2.27; 95% CI, 1.14-4.52; P = .019), low hemoglobin level at hospital admission (AOR, 0.70; 95% C...Continue Reading

References

Sep 1, 1992·Thorax·R F MillerS J Semple
Sep 1, 1992·Thorax·D M MitchellF M Moss
Nov 1, 1995·American Journal of Respiratory and Critical Care Medicine·R D HornerS C Gilman
May 29, 1999·Statistical Methods in Medical Research·J L Schafer
Jul 3, 1999·American Journal of Respiratory and Critical Care Medicine·P T DiazT L Clanton
Aug 10, 2000·American Journal of Respiratory and Critical Care Medicine·J R CurtisC L Bennett
Apr 11, 2001·The Journal of Infectious Diseases·M S DworkinT R Navin
Aug 15, 2001·Chest·H AhmadD V Sepkowitz
Sep 15, 2001·Journal of General Internal Medicine·B KimC L Bennett
Aug 3, 2002·American Journal of Respiratory and Critical Care Medicine·Alison MorrisLaurence Huang
Mar 28, 2003·The Journal of Infectious Diseases·Ann E WakefieldRobert F Miller
Jul 26, 2003·AIDS Patient Care and STDs·Joseph PulvirentiNooruzsabha Ahmed
May 1, 2004·American Journal of Respiratory and Critical Care Medicine·Alison MorrisKaren A Norris
Jun 11, 2004·The New England Journal of Medicine·Charles F Thomas, Andrew H Limper
Oct 27, 2004·Emerging Infectious Diseases·Alison MorrisJonathan E Kaplan
Jan 31, 2006·The Journal of Eukaryotic Microbiology·Scott A RedheadJames R Stringer
Sep 13, 2006·Emerging Infectious Diseases·Kieran R DalyPeter D Walzer
Mar 16, 2007·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·R F MillerJ A Cassell

❮ Previous
Next ❯

Citations

Nov 19, 2009·Molecular Genetics and Genomics : MGG·Thomas M SesterhennMelanie T Cushion
Mar 15, 2011·Parasite : Journal De La Société Française De Parasitologie·L Huang
Jan 15, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Alison Morris
Oct 18, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Taylor Eddens, Jay K Kolls
Mar 12, 2009·Current Opinion in Pulmonary Medicine·Marcelo CortiKumiko Eiguchi
Mar 7, 2012·Respirology : Official Journal of the Asian Pacific Society of Respirology·Emilia HardakIlana Oren
Apr 12, 2012·Clinical Microbiology Reviews·Alison Morris, Karen A Norris
Sep 10, 2011·Interdisciplinary Perspectives on Infectious Diseases·Jing WangFrancis Gigliotti
Jun 7, 2011·American Journal of Respiratory Cell and Molecular Biology·Oscar Perez-LealSalim Merali
Jun 23, 2011·PloS One·Anna MartinezCécile-Marie Aliouat-Denis
Jun 10, 2011·Proceedings of the American Thoracic Society·Kathleen M AkgünKristina Crothers
Jun 10, 2011·Proceedings of the American Thoracic Society·Laurence HuangUNKNOWN Lung HIV Study
Dec 22, 2009·Future Microbiology·Michelle N Kelly, Judd E Shellito
Aug 21, 2010·Future Microbiology·Olga Matos, Francisco Esteves
Nov 1, 2012·North American Journal of Medical Sciences·Oyebode Armstrong Terry AlliMusiliu Adewale Oyenike
Mar 4, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Edward M GardnerWilliam J Burman
Feb 1, 2014·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Yasufumi MatsumuraSatoshi Ichiyama
Mar 13, 2014·The Journal of Infection·Soo Jung KimJong Sun Park
Oct 9, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kpandja DjawePeter D Walzer
Jun 10, 2010·Annual Review of Microbiology·Melanie T Cushion, James R Stringer
Feb 4, 2014·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·F EstevesO Matos
Mar 28, 2013·Expert Opinion on Medical Diagnostics·Sadatomo Tasaka, Hitoshi Tokuda
Apr 29, 2011·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Hsiao-Wei WangChun-Ming Lee
May 25, 2013·Clinics in Chest Medicine·Robert F MillerPeter D Walzer
Jun 30, 2012·Revue des maladies respiratoires·N De CastroJ-M Molina
Feb 23, 2010·Infectious Disease Clinics of North America·Emilie CatherinotOlivier Lortholary
Aug 12, 2009·Acta Tropica·Stephenson W NkininEdna S Kaneshiro
Apr 21, 2009·Clinics in Chest Medicine·Bryan J KrajicekAndrew H Limper
Jan 29, 2011·Journal of Medical Microbiology·Xue-Lian WangChun-Li An
Jul 17, 2015·Open Forum Infectious Diseases·Jonathan J JulianoLaurence Huang
Apr 4, 2013·Scandinavian Journal of Infectious Diseases·Josep M LlibreBonaventura Clotet
Nov 26, 2014·Seminars in Immunopathology·Taylor Eddens, Jay K Kolls
Apr 11, 2012·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·F EstevesO Matos

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.