Early Predictors of Renal Dysfunction in Pediatric Patients with Sickle Cell Disease

Indian Journal of Nephrology
Mohamed Abdelaziz El-Gamasy, Wageh S El-Naghy

Abstract

Sickle cell disease (SCD) is a hereditary hemoglobinopathy characterized by abnormal hemoglobin production which leads to hemolytic anemia and intermittent occlusion of small blood vessels, which further leads to tissue ischemia, chronic organ damage, and organ dysfunction including urinary system. To measure the serum levels of cystatin-C and beta 2 microglobulin in pediatric patients with SCDand to investigate their significance as early biomarkers of glomerular and/or renal tubular dysfunction. This study was conducted among 70 children with SCD and 40 age and sex-matched children as a control group. All subjects underwent a full medical history, through physical examination, laboratory investigations including blood urea, serum creatinine, serum ferritin, estimated glomerular filtration rate (eGFR) using the Schwartz formula, creatinine clearance, urinary albumin/creatinine ratio, serum cystatin-C, and β-2 microglobulin levels. Pediatric patients with SCD had significantly higher serum cystatin-C and β-2 microglobulin levels compared to controls. In addition, serum cystatin-C and β-2 microglobulin levels were positively correlated with blood urea, serum creatinine, serum ferritin, urinary albumin/creatinine ratio, duration ...Continue Reading

References

Nov 1, 1987·Kidney International·G H Schardijn, L W Statius van Eps
Feb 24, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ofelia AlvarezGabriela Lopez-Mitnik
May 24, 2007·Critical Care : the Official Journal of the Critical Care Forum·José David Herrero-MorínAlberto Medina
Apr 7, 2017·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jeffrey D LebensburgerDaniel I Feig

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Methods Mentioned

BETA
electrophoresis
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

SPSS

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