Early pregnancy levels of pregnancy-associated plasma protein a and the risk of intrauterine growth restriction, premature birth, preeclampsia, and stillbirth

The Journal of Clinical Endocrinology and Metabolism
G C S SmithJ Michael Connor

Abstract

The risk of adverse perinatal outcome among 8839 women recruited to a multicenter, prospective cohort study was related to maternal circulating concentrations of trophoblast-derived proteins at 8-14 wk gestation. Women with a pregnancy-associated plasma protein A (PAPP-A) in the lowest fifth percentile at 8-14 wk gestation had an increased risk of intrauterine growth restriction [adjusted odds ratio, 2.9; 95% confidence interval (CI), 2.0-4.1], extremely premature delivery (adjusted odds ratio, 2.9; 95% CI, 1.6-5.5), moderately premature delivery (adjusted odds ratio, 2.4; 95% CI, 1.7-3.5), preeclampsia (adjusted odds ratio, 2.3; 95% CI, 1.6-3.3), and stillbirth (adjusted odds ratio, 3.6; 95% CI, 1.2-11.0). The strengths of the associations were similar when the test was performed before 13 wk gestation or between 13 and 14 wk gestation. In contrast, levels of free beta-human CG, another circulating protein synthesized by the syncytiotrophoblast, were not predictive of later outcome in multivariate analysis. PAPP-A has been identified as a protease specific for IGF binding proteins. We conclude that control of the IGF system in the first and early second trimester trophoblast may have a key role in determining subsequent pregna...Continue Reading

References

Mar 1, 1987·Baillière's Clinical Obstetrics and Gynaecology·A Klopper
Aug 1, 1995·Acta Obstetricia Et Gynecologica Scandinavica·J F PedersenS Ruge
Aug 29, 1998·Molecular and Cellular Endocrinology·D R Clemmons
Aug 29, 1998·Molecular and Cellular Endocrinology·M van KleffensS L Drop
Dec 17, 1998·The New England Journal of Medicine·G C SmithJ E Fleming
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·J B LawrenceC A Conover
Feb 26, 2000·Human Reproduction·J C IrwinL C Giudice

❮ Previous
Next ❯

Citations

May 20, 2004·Proceedings of the National Academy of Sciences of the United States of America·C P SibleyM Constância
Jul 26, 2005·Proceedings of the National Academy of Sciences of the United States of America·Qing QiuAndrée Gruslin
Nov 3, 2009·Molecular Human Reproduction·Fuller W BazerKayla Bayless
Apr 7, 2010·The Journal of Clinical Investigation·Hyunjung Jade Lim, Haibin Wang
Jul 11, 2009·BMC Medical Research Methodology·Samantha J LainChristine L Roberts
Jul 16, 2009·Reproductive Biology and Endocrinology : RB&E·Simon GrillOlav Lapaire
Jul 21, 2010·Reproductive Biology and Endocrinology : RB&E·Pamela K Wagner, Julian K Christians
Apr 19, 2011·Reproductive Biology and Endocrinology : RB&E·Pamela K WagnerJulian K Christians
Jan 28, 2009·Fertility and Sterility·Reija KlemettiElina Hemminki
Nov 12, 2013·Journal de gynécologie, obstétrique et biologie de la reproduction·L J Salomon, V Malan
Nov 28, 2012·Histochemistry and Cell Biology·Ambrogio P LonderoLaura Mariuzzi
May 3, 2011·Archives of Gynecology and Obstetrics·Alev AtisNimet Goker
Jun 18, 2009·Cancer Causes & Control : CCC·Anna Carita Callan, Elizabeth Milne
Feb 20, 2016·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Shridevi GunduPrakash Gambhir
Feb 10, 2016·Gynécologie, obstétrique & fertilité·A BouzidM Mourali
Apr 27, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Huriye Ayse ParlakgumusEbru Tarim
Jun 26, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Mehmet Fatih KarsliMustafa Ugur
Oct 13, 2011·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Ioannis PapastefanouDemetrios Kassanos
Sep 15, 2015·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·P SirikunalaiT Tongsong
Jul 3, 2015·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Mehmet Fatih KarsliTuncay Kucukozkan
May 10, 2013·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Banu DaneRamazan Dansuk
Sep 8, 2012·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Sevsen KulaksizogluSuna Turkoglu
Jan 1, 2014·Journal of Clinical Medicine·David KrantzJonathan Carmichael
Aug 8, 2015·International Journal of Molecular Sciences·Hee Jin ParkDong Hyun Cha
Jan 27, 2016·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Manisha KumarMujeeb U Rehman
Oct 30, 2015·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Antonio Simone LaganàSandro Gerli
Feb 24, 2016·Women's Health·Neil O'GormanLiona C Y Poon
Dec 24, 2003·Prenatal Diagnosis·Jennie LaigaardUlla M Wewer
Apr 3, 2012·Trends in Endocrinology and Metabolism : TEM·Cheryl A Conover
Oct 12, 2011·Clinical Biochemistry·Alexandra MuravskáMarta Kalousová
Nov 7, 2015·Clinical Chemistry and Laboratory Medicine : CCLM·Young Bae HansenSteen Sørensen
Apr 13, 2011·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Jenni K RantaSeppo Heinonen
Mar 1, 2011·Clinics in Perinatology·Methodius G Tuuli, Anthony O Odibo
Mar 1, 2011·Clinics in Perinatology·Jason Gardosi
Jul 20, 2010·Clinics in Laboratory Medicine·Laura Goetzl
Apr 1, 2008·Placenta·M BuimerC Ris-Stalpers

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
M B Landon, S Vickers
© 2022 Meta ULC. All rights reserved