Early pregnancy plasminogen activator inhibitor-1 levels in Nigerian women and its relationship with preeclampsia

Nigerian Journal of Clinical Practice
Ifeoma UdenzeChristian Chigozie Makwe

Abstract

This study compared early plasma levels of plasminogen activator inhibitor-1 (PAI-1) in normal pregnancy and preeclampsia and determined its relationship with disease severity. This was a prospective cohort study of 195 normotensive, aproteinuric pregnant women without prior history of gestational hypertension. The women were attending the Antenatal Clinic at The Lagos University Teaching Hospital and were within 24 weeks gestation at recruitment. The outcome measures were PAI-1, systolic blood pressure (SBP), diastolic blood pressure (DBP), and significant proteinuria. The endpoint of the study was the development of preeclampsia. The diagnosis of preeclampsia was made by the attending Obstetrician. The data were analyzed using the IBM SPSS statistical software. Statistical significance was set at P < 0.05. First trimester PAI-1 levels were significantly higher in the women who later developed preeclampsia compared to those who had a normal pregnancy (P < 0.0001). In these group of women who later developed preeclampsia, PAI-1 had an inverse relationship with gestational age (r = 0.878) whereas in normal pregnancy, PAI-1 and gestational age had a direct relationship (r = 0.017). Second trimester systolic and DBP values were al...Continue Reading

References

Aug 16, 1969·British Medical Journal·J BonnarA S Douglas
Jan 1, 1984·Journal of Clinical Pathology·L GowD Ogston
Apr 1, 1993·British Journal of Obstetrics and Gynaecology·A ReithB Bennett
Feb 1, 1996·The Journal of Obstetrics and Gynaecology Research·M GaoY Takeda
Nov 27, 1999·Obstetrics and Gynecology·P M BosioC O'Herlihy
Jul 10, 2003·Obstetrics and Gynecology·Baha M Sibai
Oct 7, 2010·Cardiovascular & Hematological Agents in Medicinal Chemistry·Ossama M Reslan, Raouf A Khalil

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Citations

Feb 15, 2019·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Flávia Campos LucenaLuci Maria SantAna Dusse

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