Early pregnancy protein multiplex screening reflects circulating and urinary divergences associated with the development of preeclampsia

Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy
Margarita L Martinez-FierroYolanda Ortiz-Castro

Abstract

Preeclampsia, a pregnancy disorder characterized by hypertension and proteinuria, represents the leading cause of fetal and maternal morbidity and mortality in developing countries. The identification of novel and accurate biomarkers that are predictive of preeclampsia is necessary to improve the prognosis of patients with preeclampsia. To evaluate the preeclampsia predictive value of 34 angiogenic-related proteins. We performed a nested cohort case-control study of pregnant women. The profile of the 34 proteins was evaluated at 12, 16, and 20 gestational weeks (GWs), using urine/plasma from 16 women who developed preeclampsia and 20 normotensive pregnant controls by Bio-Plex ProTM Human Cancer Biomarker Panels 1 and 2. The urine concentration of soluble epidermal growth factor receptor (sEGFR), hepatocyte growth factor (HGF), angiopoietin-2 (ANG-2), endoglin (ENG), soluble fas ligand (sFASL), interleukin 6 (IL-6), placental growth factor (PLGF), and vascular endothelial growth factor A (VEGF-A) at 12 GW, prolactin (PRL), ANG-2, transforming growth factor alpha (TGF-α), and VEGF-A at 16 GW, and soluble IL-6 receptor alpha (sIL-6Rα), ANG-2 and sFASL at 20 GW, were different between groups (p < 0.05). The concentration cut-off va...Continue Reading

References

Dec 1, 1992·Scandinavian Journal of Clinical and Laboratory Investigation·A BernardM van Lierde
May 1, 1987·Pacing and Clinical Electrophysiology : PACE·D G WyseA K Brownell
Feb 1, 1974·The Journal of Cell Biology·R Rodewald, M J Karnovsky
Jan 9, 2003·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Maria HohlagschwandtnerPeter Husslein
Apr 6, 2004·Clinical Chemistry and Laboratory Medicine : CCLM·Chantal TseSerge Uzan
Jan 6, 2005·JAMA : the Journal of the American Medical Association·Richard J LevineS Ananth Karumanchi
Jan 6, 2006·Kidney International·P K AggarwalV Jha
Mar 3, 2007·Journal of the American Society of Nephrology : JASN·Danilo FliserHarald Mischak
May 8, 2008·The Journal of Clinical Endocrinology and Metabolism·Alfredo Leaños-MirandaAlfredo Ulloa-Aguirre
Feb 18, 2010·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Giovanna OggèSonia S Hassan
Jan 5, 2011·Hypertension·David M CartyChristian Delles
Jun 12, 2012·International Journal of Nephrology·Akihiro Tojo, Satoshi Kinugasa
Aug 22, 2012·Fetal Diagnosis and Therapy·Ranjit AkolekarKypros H Nicolaides
Aug 24, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Merih BayramMelek Yaman
Nov 3, 2012·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Ga Hyun SonJung Hwa Park
Jun 21, 2013·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Zhan ZhangHe Li
Aug 21, 2013·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Jing XiaoYong Gu
Dec 4, 2013·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·M L Martinez-FierroC Castruita-De la Rosa
Mar 19, 2014·PloS One·Marie AustdalTone Frost Bathen
Jun 11, 2014·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·A KhalilK H Nicolaides
Oct 29, 2014·Nucleic Acids Research·UNKNOWN UniProt Consortium
Dec 3, 2014·International Journal of Cardiology·Margarita L Martinez-FierroMaria E Castañeda-Lopez
Mar 18, 2015·Experimental and Therapeutic Medicine·D KappouD A Spandidos
Mar 19, 2016·Prenatal Diagnosis·Alejandra ChaparroSebastián Enrique Illanes
Sep 23, 2016·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Indira KosovicSandra Zekic Tomas
Dec 13, 2016·Medicina·Viktorija TarasevičienėRegina Mačiulevičienė
May 12, 2017·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Laura EhrlichStefan Verlohren
Jun 1, 2017·Iranian Biomedical Journal·Pooneh NikueiAli AtashAbParvar
Sep 20, 2017·Proceedings of the National Academy of Sciences of the United States of America·Tamara Garrido-GomezCarlos Simón
Dec 6, 2018·Schweizer Archiv für Tierheilkunde·S EgloffS Peterhans

❮ Previous
Next ❯

Citations

Oct 3, 2018·Scandinavian Journal of Clinical and Laboratory Investigation·Ilya Valerevich SmirnovVladimir Borisovich Klimovich
Mar 20, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Claudia Castruita-De la RosaMargarita L Martinez-Fierro
May 1, 2021·Cells·Margarita L Martinez-Fierro, Idalia Garza-Veloz
Jul 21, 2021·International Journal of Environmental Research and Public Health·Małgorzata Lewandowska

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
Margarita L Martinez-FierroJose M Ortiz-Rodriguez
Acta Obstetricia Et Gynecologica Scandinavica
Antonio De VivoRosario D'anna
Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy
Nokuzola MbheleThajasvarie Naicker
© 2022 Meta ULC. All rights reserved