Early Pregnancy Serum Metabolite Profiles Associated with Hypertensive Disorders of Pregnancy in African American Women: A Pilot Study.

Journal of Pregnancy
Erin P FerrantiAnne L Dunlop

Abstract

Hypertensive disorders of pregnancy (HDP) are the most common cardiometabolic complications of pregnancy, affecting nearly 10% of US pregnancies and contributing substantially to maternal and infant morbidity and mortality. In the US, women of African American race are at increased risk for HDP. Early biomarkers that reliably identify women at risk for HDP remain elusive, yet are essential for the early identification and targeting of interventions to improve maternal and infant outcomes. We employed high-resolution metabolomics (HRM) to identify metabolites and metabolic pathways that were altered in early (8-14 weeks) gestation serum samples of pregnant African American women who developed HDP after 20 weeks' gestation (n = 20)-either preeclampsia (PE; n = 11) or gestational hypertension (gHTN; n = 9)-compared to those who delivered full term without complications (n = 80). We found four metabolic pathways that were significantly (p < 0.05) altered in women who developed PE and five pathways that were significantly (p < 0.05) altered in women who developed gHTN compared to women who delivered full term without complications. We also found that four specific metabolites (p < 0.05) were distinctly upregulated (retinoate, kynure...Continue Reading

Associated Clinical Trials

May 10, 2021·Ndidiamaka Amutah-OnukaghaNdidiamaka Amutah-Onukagha

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Citations

Jan 9, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Nuno R CoelhoEmília C Monteiro
Aug 22, 2021·International Journal of Cancer. Journal International Du Cancer·Kan Hong ZhengLina Mu

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Methods Mentioned

BETA
blood draw
nuclear magnetic resonance

Software Mentioned

xmsPANDA
ComBat
xMSannotator
Mummichog
apLCMS
METLIN
xMSanalyzer
R

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