Early prognostic factors in patients with acute renal failure requiring dialysis

Renal Failure
I-Kuan WangFeng-Rong Chuang

Abstract

Despite improvements in renal therapy and technology, the mortality rate of patients with acute renal failure (ARF) remains high. Because ARF is a heterogeneous syndrome, occurring in patients with diverse etiologies and comorbid conditions, predicting its outcome is difficult. This study aims to identify early clinical and laboratory prognostic factors, including acute-phase reactants such as C-reactive protein (CRP), fibrinogen, and albumin, in ARF patients requiring dialysis. From June 2002 to March 2004, 61 patients with ARF requiring dialysis at Chang Gung Memorial Hospital, Chiayi, were prospectively analyzed. For each patient, the worst values of prognostic variables 24 hr before starting dialysis were prospectively assessed. Oliguria, low plasma fibrinogen levels, hypotension, cardiac disease, and neoplastic disease were statistically significant in predicting hospital mortality. Using Youden's index, the best cut-off value for plasma fibrinogen in predicting mortality was 300 mg/dL with a sensitivity and specificity of 61% and 96%, respectively. Serum CRP and serum albumin were not predictive of hospital mortality. Early prognostic factors in predicting mortality for patients with ARF requiring dialysis identified by m...Continue Reading

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Citations

Dec 11, 2007·Renal Failure·Savas OzturkMehmet Sukru Sever
Jul 16, 2010·JPEN. Journal of Parenteral and Enteral Nutrition·Rex O BrownUNKNOWN American Society for Parenteral and Enteral Nutrition Board of Directors

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