Early Progressive Changes in White Matter Integrity Are Associated with Stroke Recovery.

Translational Stroke Research
Daniela PinterChristian Enzinger

Abstract

Information on microstructural white matter integrity has been shown to explain post-stroke recovery beyond clinical measures and focal brain damage. Especially, knowledge about early white matter changes might improve prediction of outcome. We investigated 42 acute reperfused ischemic stroke patients (mean age 66.5 years, 40% female, median admission NIHSS 9.5) with a symptomatic MRI-confirmed unilateral middle cerebral artery territory infarction 24-72 h post-stroke and after 3 months. All patients underwent neurological examination and brain MRI. Fifteen older healthy controls (mean age 57.3 years) were also scanned twice. We assessed fractional anisotropy (FA), mean diffusivity (MD), axial (AD), and radial diffusivity (RD). Patients showed significantly decreased white matter integrity in the hemisphere affected by the acute infarction 24-72 h post-stroke, which further decreased over 3 months compared with controls. Less decrease in FA of remote white matter tracts was associated with better stroke recovery even after correcting for infarct location and extent. A regression model including baseline information showed that the modified Rankin Scale and mean FA of the genu of the corpus callosum explained 53.5% of the varian...Continue Reading

References

Aug 1, 1987·AJR. American Journal of Roentgenology·F FazekasR A Zimmerman
Oct 12, 2002·Proceedings of the National Academy of Sciences of the United States of America·Heidi Johansen-BergPaul M Matthews
Aug 16, 2005·Biophysical Journal·Pabitra N Sen, Peter J Basser
Aug 5, 2006·Journal of Magnetic Resonance Imaging : JMRI·Rakesh K GuptaPonnada A Narayana
Jun 30, 2007·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Andrew L AlexanderAaron S Field
Apr 3, 2009·NeuroRehabilitation·Sung Ho JangYoung Hyun Kwon
Nov 29, 2011·NeuroImage·Denis Le Bihan, Heidi Johansen-Berg
Mar 22, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Basia A RadlinskaAlexander Thiel
Jan 30, 2015·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Cameron S MangLara A Boyd
Apr 1, 2016·Neurology·Ethan PaniGottfried Schlaug
Aug 27, 2016·The Neuroradiology Journal·Lamiaa El-SerougyAhmad El-Morsy
Sep 18, 2016·Lancet·Graeme J Hankey
Dec 31, 2016·Annals of Neurology·Rebecca A Betensky
Jan 13, 2017·Stroke; a Journal of Cerebral Circulation·Patrick Lyden
Feb 25, 2017·Nature Reviews. Neurology·Elad I Levy, Maxim Mokin
Mar 30, 2017·NeuroImage. Clinical·Jill Campbell StewartSteven C Cramer
Apr 4, 2017·Clinical Medicine : Journal of the Royal College of Physicians of London·Salwa El Tawil, Keith W Muir
Aug 31, 2018·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Milanka M VisserAndrew Bivard
Oct 26, 2018·Stroke; a Journal of Cerebral Circulation·Josep PuigSalvador Pedraza
Jan 30, 2019·Translational Stroke Research·Mark R EthertonNatalia S Rost
May 15, 2019·Journal of Computer Assisted Tomography·Ahmed Abdelzaher AbdelrasoulAhmed Abdel Khalek Abdel Razek
May 15, 2019·Journal of Computer Assisted Tomography·Ahmed Abdelzaher AbdelrasoulAhmed Abdel Khalek Abdel Razek
Jan 8, 2020·Stroke; a Journal of Cerebral Circulation·Sharmila SagnierIgor Sibon

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Software Mentioned

Statistical Package of Social Science ( SPSS Statistics
fslmaths
TBSS
fMRIB s Diffusion Toolbox
Prisma
FSL
Juelich

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