Early propranolol after traumatic brain injury is associated with lower mortality

The Journal of Trauma and Acute Care Surgery
Ara KoEric J Ley

Abstract

β-Adrenergic receptor blockers (BBs) administered after trauma blunt the cascade of immune and inflammatory changes associated with injury. BBs are associated with improved outcomes after traumatic brain injury (TBI). Propranolol may be an ideal BB because of its nonselective inhibition and ability to cross the blood-brain barrier. We determined if early administration of propranolol after TBI is associated with lower mortality. All adults (age ≥ 18 years) with moderate-to-severe TBI (head Abbreviated Injury Scale [AIS] score, 3-5) requiring intensive care unit (ICU) admission at a Level I trauma center from January 1, 2013, to May 31, 2015, were prospectively entered into a database. Administration of early propranolol was dosed within 24 hours of admission at 1 mg intravenous every 6 hours. Patients who received early propranolol after TBI (EPAT) were compared with those who did not (non-EPAT). Data including demographics, hospital length of stay (LOS), ICU LOS, and mortality were collected. Over 29 months, 440 patients with moderate-to-severe TBI met inclusion criteria. Early propranolol was administered to 25% (109 of 440) of the patients. The EPAT cohort was younger (49.6 years vs. 60.4 years, p < 0.001), had lower Glasgow...Continue Reading

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Citations

Sep 13, 2016·Frontiers in Synaptic Neuroscience·Marco AtzoriHumberto Salgado
Jan 6, 2018·Journal of Neurosurgery·Ayman El-MenyarHassan Al-Thani
Dec 14, 2019·PloS One·Stephanie C DreckmannMarc G Jeschke
Oct 7, 2017·Cardiology in Review·Ayman El-MenyarWilliam Frishman
Aug 31, 2019·Trauma Surgery & Acute Care Open·Thomas J SchroeppelTimothy C Fabian
Dec 19, 2017·The Journal of Trauma and Acute Care Surgery·Eric J LeyUNKNOWN Beta Blockers TBI Study Group Collaborators
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Feb 1, 2020·World Journal of Surgery·Hosseinali KhaliliShahin Mohseni
Jun 18, 2019·Current Surgery Reports·Henry W Caplan, Charles S Cox
Nov 20, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Michael M GezalianShouri Lahiri
Jan 27, 2021·Trends in Neurosciences·Alan I FadenRebecca J Henry
Jan 23, 2021·Neurological Research·William A Florez-PerdomoLuis Rafael Moscote-Salazar
Jan 27, 2021·The Journal of Trauma and Acute Care Surgery·Huaqiang DingLiang Liu
May 4, 2021·The Journal of Trauma and Acute Care Surgery·Kathleen E SingerMichael D Goodman

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