Early pulmonary events of nose-only water pipe (shisha) smoking exposure in mice

Physiological Reports
Abderrahim NemmarErnest Adeghate

Abstract

Water pipe smoking (WPS) is increasing in popularity and prevalence worldwide. Convincing data suggest that the toxicants in WPS are similar to that of cigarette smoke. However, the underlying pathophysiologic mechanisms related to the early pulmonary events of WPS exposure are not understood. Here, we evaluated the early pulmonary events of nose-only exposure to mainstream WPS generated by commercially available honey flavored "moasel" tobacco. BALB/c mice were exposed to WPS 30 min/day for 5 days. Control mice were exposed using the same protocol to atmospheric air only. We measured airway resistance using forced oscillation technique, and pulmonary inflammation was evaluated histopathologically and by biochemical analysis of bronchoalveolar lavage (BAL) fluid and lung tissue. Lung oxidative stress was evaluated biochemically by measuring the level of reactive oxygen species (ROS), lipid peroxidation (LPO), reduced glutathione (GSH), catalase, and superoxide dismutase (SOD). Mice exposed to WPS showed a significant increase in the number of neutrophils (P < 0.05) and lymphocytes (P < 0.001). Moreover, total protein (P < 0.05), lactate dehydrogenase (P < 0.005), and endothelin (P < 0.05) levels were augmented in bronchoalveola...Continue Reading

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Citations

May 24, 2017·Chronic Respiratory Disease·Mehrzad BahtoueeFatemeh Nekouee
Jun 13, 2017·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Anas A AshourAla-Eddin Al Moustafa
Jan 20, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Abderrahim NemmarBadreldin H Ali
Feb 9, 2018·Physiological Reports·Naushad Ahmad KhanIrfan Rahman
Dec 13, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Abderrahim NemmarBadreldin H Ali
Jul 26, 2019·Oxidative Medicine and Cellular Longevity·Badreldin H AliAbderrahim Nemmar
Jan 15, 2019·Journal of Translational Internal Medicine·Sankalp Yadav, Gautam Rawal
Apr 20, 2017·Frontiers in Physiology·Badreldin H AliAbderrahim Nemmar
Mar 16, 2021·American Journal of Physiology. Lung Cellular and Molecular Physiology·Abderrahim NemmarBadreldin H Ali

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Methods Mentioned

BETA
bronchoalveolar lavage
lavage
ELISA
light microscopy

Software Mentioned

FlexiVent
GraphPad Prism

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