Early radiation exposures and BRCA1-associated breast cancer in young women from Poland

Breast Cancer Research and Treatment
Jacek GronwaldSteven A Narod

Abstract

To study whether or not there is an adverse effect of early chest X-rays on breast cancer risk in breast cancer susceptibility gene 1 (BRCA1) carriers, we compared the histories of chest X-ray exposures before age 30 in 138 BRCA1 carriers with breast cancer with 158 age-matched women with breast cancer, but without a BRCA1 mutation. All cases were drawn from a national breast cancer research registry. Affected carriers reported more frequent chest X-ray use before age 20 than affected non-carriers (0.6 vs. 0.3; P = 0.01). Affected carriers had, on average, 1.8 chest X-rays before age 30 compared to an average of 1.0 for affected non-carriers (P = 0.002). The odds ratio for ever having had a chest X-ray below age 30, given a BRCA1 mutation, was 1.8 [95% confidence interval (CI) = 1.2-2.9; P = 0.01]. These observations support the hypothesis that early radiation exposure may be a risk factor for breast cancer in BRCA1 carriers.

References

Sep 6, 1989·Journal of the National Cancer Institute·D A HoffmanJ D Boice
Feb 8, 2002·Cell·Ashok R Venkitaraman
Jul 11, 2002·Radiation Research·Dale L PrestonJohn D Boice
Jul 3, 2003·Journal of the National Cancer Institute·Flora E van LeeuwenNicola S Russell
May 18, 2004·International Journal of Cancer. Journal International Du Cancer·Bohdan GórskiJan Lubiński
Mar 17, 2006·Breast Cancer Research and Treatment·J LubińskiS A Narod
May 2, 2006·The Lancet Oncology·Steven A NarodUNKNOWN Hereditary Breast Cancer Clinical Study Group
Nov 23, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Deborah GoldfrankMark Robson

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Citations

May 28, 2008·Breast Cancer Research and Treatment·Magdalena Chechlinska, Radoslawa Nowak
Feb 4, 2012·Australasian Physical & Engineering Sciences in Medicine·R K GrewalN Sabharwal
Oct 24, 2012·Annals of the ICRP·N J Kleiman
Jul 18, 2014·Annals of Surgical Oncology·David Euhus
Jan 13, 2010·European Journal of Epidemiology·Anouk PijpeUNKNOWN Hereditary Breast and Ovarian Cancer Study, the Netherlands
Mar 2, 2012·Women's Health·Leonardo Salmena, Steven Narod
Mar 8, 2013·The Surgical Clinics of North America·David M Euhus, Linda Robinson
Jan 19, 2010·Cancer Letters·Naghma KhanHasan Mukhtar
Dec 1, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Marcel J W GreuterGeertruida H de Bock
Aug 13, 2011·International Journal of Cancer. Journal International Du Cancer·Jan LubinskiUNKNOWN Hereditary Breast Cancer Clinical Study Group
Sep 14, 2015·Surgical Oncology Clinics of North America·Jeffrey N Weitzel
Sep 1, 2015·The Surgical Clinics of North America·David EuhusNagi F Khouri
Aug 2, 2015·Current Environmental Health Reports·Cari M KitaharaAmy Berrington de González
Aug 2, 2014·Breast Cancer Research and Treatment·Vasily GiannakeasSteven A Narod
May 18, 2016·Breast Cancer Research : BCR·Annelot BaertAnne Vral
Jul 16, 2013·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Esther M JohnAlice S Whittemore

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