PMID: 2121948Nov 1, 1990Paper

Early randomized intervention with high-frequency jet ventilation in respiratory distress syndrome

The Journal of Pediatrics
W A CarloR J Martin

Abstract

To determine whether early use of high-frequency jet ventilation reduces neonatal mortality or pulmonary morbidity rates, we randomly selected 42 infants with clinical and radiographic evidence of severe respiratory distress syndrome to receive either high-frequency jet ventilation or conventional ventilation. Separate sequential analyses (two-sided, alpha = 0.05, power = 0.95 to detect 85:15 advantage) were performed for mortality rates, air leaks, bronchopulmonary dysplasia, intraventricular hemorrhage, and assignment crossover, and a combined analysis was performed, with death overriding other outcome variables. Enrollment was completed when the combined analysis reached the sequential design boundary indicating no treatment difference. Mortality rates (19% among infants receiving high-frequency jet ventilation vs 24% among infants receiving conventional ventilation), the incidence of air leaks (48% vs 52%), bronchopulmonary dysplasia (39% vs 41%), and intraventricular hemorrhage (33% vs 43%), and assignment crossovers (14% vs 24%) did not differs significantly between the treatment groups. We conclude that early use of high-frequency jet ventilation does not prevent or substantially reduce mortality or morbidity rates assoc...Continue Reading

Citations

Jul 8, 1998·Pediatric Clinics of North America·M C McGettiganJ P Goldsmith
Sep 26, 2001·Clinics in Perinatology·M Keszler, D J Durand
Jun 9, 2005·Archives of Disease in Childhood. Fetal and Neonatal Edition·U H ThomeF Pohlandt
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Nov 3, 2010·Best Practice & Research. Clinical Anaesthesiology·Walid Habre
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Oct 1, 2009·Journal of Clinical Epidemiology·Johanna H van der LeeMartin Offringa
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