Early Rapid Neurological Assessment for Acute Spinal Cord Injury Trials

Journal of Neurotrauma
Camila R BattistuzzoPeter E Batchelor

Abstract

Clinical trials evaluating early therapies after spinal cord injury (SCI) are challenging because of the absence of a rapid assessment. The aim of this study was to determine whether the severity and level of SCI could be established from a brief neurological assessment capable of being used in an emergency setting. A brief assessment called the SPinal Emergency Evaluation of Deficits (SPEED) was developed and retrospectively evaluated in a cohort of 118 patients with SCI. Foot motor and sensory function was used to indicate injury severity. C3 dermatome sensation, handgrip strength and location of spinal pain were used to indicate the level of injury. With regard to injury severity, a high proportion of patients (94%) with no foot movement at the time of injury were initially diagnosed as motor complete (American Spinal Injury Association Impairment Scale [AIS] grade A-B), whereas all patients with foot movement were identified as motor incomplete (AIS grade C-D). This was reflected by a good correlation (rs = 0.79) and agreement (κ = 0.85) between the SPEED motor score and the acute hospital assessment. With respect to injury level, the majority of cases with cervical SCI (92%) had no or weak handgrip at the time of paramedic...Continue Reading

References

Jun 2, 2016·Therapeutic Hypothermia and Temperature Management·Peter E BatchelorJustin Lundbye
Aug 28, 2019·Experimental Biology and Medicine·Shu-Qin DingHe-Zuo Lü

Citations

Nov 11, 1992·Paraplegia·K S CrozierJohn F Ditunno
Mar 1, 1989·Injury·Y Folman, W el Masri
Oct 1, 1993·American Journal of Physical Medicine & Rehabilitation·D M BlausteinJohn F Ditunno
Nov 20, 1998·Archives of Physical Medicine and Rehabilitation·Steven C Kirshblum, K C O'Connor
Mar 24, 2004·Spinal Cord·John F DitunnoA S Burns
Jul 13, 2004·The Spine Journal : Official Journal of the North American Spine Society·W P Coleman, Fred H Geisler
Dec 21, 2006·Spinal Cord·John D SteevesInternational Campaign for Cures of Spinal Cord Injury Paralysis
Sep 20, 2007·Journal of Neurosurgery. Spine·Daniel R FassettAshwini D Sharan
May 28, 2010·Journal of Neurotrauma·Peter E BatchelorDavid W Howells
Jan 22, 2011·Journal of Neurotrauma·Peter E BatchelorDavid W Howells
Oct 25, 2011·Critical Care Medicine·Stephen A BernardRapid Infusion of Cold Hartmanns Investigators
Feb 15, 2012·The Journal of Spinal Cord Medicine·Steven C KirshblumWilliam Waring
Dec 12, 2012·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Jefferson R WilsonMichael G Fehlings
Dec 15, 2012·Topics in Spinal Cord Injury Rehabilitation·John D SteevesKim D Anderson

Related Concepts

Study
Malignant Neoplasm of Spinal Cord
Thoracolumbar
Neoplasm of Uncertain or Unknown Behavior of Spinal Cord
Evaluation
Dermatome Region
Biochar
Neck
Grade
Pain in Spine

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Sexual Dimorphism in Neurodegeneration

There exist sex differences in neurodevelopmental and neurodegenerative disorders. For instance, multiple sclerosis is more common in women, whereas Parkinson’s disease is more common in men. Here is the latest research on sexual dimorphism in neurodegeneration

HLA Genetic Variation

HLA genetic variation has been found to confer risk for a wide variety of diseases. Identifying these associations and understanding their molecular mechanisms is ongoing and holds promise for the development of therapeutics. Find the latest research on HLA genetic variation here.

Super-resolution Microscopy

Super-resolution microscopy is the term commonly given to fluorescence microscopy techniques with resolutions that are not limited by the diffraction of light. Here are the latest discoveries pertaining to super-resolution microscopy.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Brain Lower Grade Glioma

Low grade gliomas in the brain form from oligodendrocytes and astrocytes and are the slowest-growing glioma in adults. Discover the latest research on these brain tumors here.

CD4/CD8 Signaling

Cluster of differentiation 4 and 8 (CD8 and CD8) are glycoproteins founds on the surface of immune cells. Here is the latest research on their role in cell signaling pathways.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.