Early real-world effectiveness of ustekinumab for Crohn's disease

Frontline Gastroenterology
Richard James HarrisJ R Fraser Cummings

Abstract

To understand the effectiveness of ustekinumab in treating Crohn's disease (CD) in a UK real-world setting. Retrospective cohort study using prospectively maintained clinical records. Single UK inflammatory bowel disease centre. Adult patients with an established diagnosis of CD prescribed ustekinumab outside of clinical trials at University Hospital Southampton (UHS). Ustekinumab, a monoclonal antibody to the shared p40 subunit of interleukin (IL) 12 and IL-23 as part of routine clinical care. Effectiveness as measured by an improvement in physician's global assessment, drug persistence and improvement in biomarkers (C-reactive protein (CRP), albumin and calprotectin). 84 patients were included, 72 had a postinduction review and 49 had 1-year data. At postinduction clinical review, clinical response occurred in 53% of patients and clinical remission occurred in 8%. For patients on ustekinumab at 1 year, clinical response occurred in 71% and remission in 14%. Adverse events included four patients with infections requiring admission, one drug-related rash, five CD surgeries and two CD exacerbations. Ustekinumab was well tolerated in a complex UK CD population and demonstrated benefit to patients in terms of clinical response and...Continue Reading

References

Dec 14, 2016·The New England Journal of Medicine·Brian G FeaganUNKNOWN UNITI–IM-UNITI Study Group
Apr 4, 2017·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Robert BattatWaqqas Afif
Jan 10, 2018·Alimentary Pharmacology & Therapeutics·P WilsUNKNOWN Groupe d'Etude Thérapeutique des Affections Inflammatoires du Tube Digestif (GETAID)
Feb 8, 2018·Gastroenterology·Omoniyi J AdedokunWilliam J Sandborn
May 26, 2018·Alimentary Pharmacology & Therapeutics·W J SandbornB G Feagan
Aug 2, 2018·International Journal of Molecular Sciences·Samuel O AdegbolaPhilip Tozer
Oct 21, 2018·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·D MegeF Michelassi
Nov 28, 2018·Nature Reviews. Gastroenterology & Hepatology·Alexander R MoschenTim Raine

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Citations

Jan 1, 2021·Journal of Gastroenterology and Hepatology·Nikolas PlevrisCharlie W Lees
Mar 17, 2021·Digestive Diseases and Sciences·Sailish HonapMark A Samaan
Mar 19, 2021·JGH Open : an Open Access Journal of Gastroenterology and Hepatology·Anna ViolaUNKNOWN “Sicilian Network for Inflammatory Bowel Disease (SN‐IBD)”
Apr 7, 2021·Scandinavian Journal of Gastroenterology·Taina SipponenUNKNOWN FINUSTE Study group
Jun 8, 2021·Digestive Diseases and Sciences·Chiara RocchiDario Sorrentino
Jun 25, 2021·Biologics : Targets & Therapy·Tzu Hsiang ChienTom Hsun-Wei Huang
Jun 29, 2021·Journal of Gastroenterology and Hepatology·Seiji YokoyamaTakayuki Matsumoto

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