PMID: 9645264Jun 30, 1998Paper

Early recognition of pregnancy by the maternal immune system

American Journal of Reproductive Immunology : AJRI
K KelemenJ Szekeres-Bartho

Abstract

Immunologic recognition of pregnancy is important for normal gestation. Successful pregnancy is characterized by a Th2 dominance, whereas there is a Th1 dominance in failed pregnancies. We assume that a signal given by the fertilized ovum induces a Th2 shift, necessary for a normal outcome. In vitro fertilization provides a tool for testing this possibility. Phytohemagglutinin-stimulated lymphocytes were incubated for 48 hr in the presence of culture media from in vitro fertilized eggs, as well as in follicular fluid (FF) and control supernatants. Total RNA was isolated from the lymphocytes by the guanidine-isothiocyanate method and interleukin (IL)-10 mRNA expression was detected by reverse transcription-polymerase chain reaction. Ten percent of the activated lymphocytes incubated with FF expressed IL-10 mRNA, whereas 88% of the lymphocytes activated with supernatants of sperm + oocytes gave a positive signal. Significantly (P < 0.05) fewer (50%) lymphocytes stimulated in the presence of control supernatants also expressed mRNA for IL-10. In supernatants of activated lymphocytes incubated with the culture medium of spermia + oocytes, the concentration of IL-10 was significantly higher than in the lymphocytes incubated with FF....Continue Reading

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Citations

May 23, 2001·Fertility and Sterility·J H CheckN M Lamborne
Aug 5, 2000·Journal of Reproductive Immunology·S Saito
Jan 15, 2002·European Journal of Obstetrics, Gynecology, and Reproductive Biology·K ManolopoulosG A Braems
Jan 22, 2003·Animal Reproduction Science·S Schäfer-Somi
Jun 16, 2001·International Immunopharmacology·J Szekeres-BarthoL Szereday
Jan 26, 2013·Animal Health Research Reviews·Keith P Poulsen, Charles J Czuprynski
Jan 13, 2000·Clinical and Experimental Immunology·N KruseP Rieckmann
Dec 2, 1999·American Journal of Reproductive Immunology : AJRI·S SaitoN Narita
Jun 22, 1999·American Journal of Reproductive Immunology : AJRI·D A Clark
Aug 3, 1999·American Journal of Reproductive Immunology : AJRI·J Szekeres-BarthoL Szereday
May 1, 2010·The Journal of Reproduction and Development·Izabela Woclawek-PotockaDariusz Jan Skarzynski
Aug 6, 2008·The Journal of Reproduction and Development·Izabela Woclawek-PotockaDariusz Jan Skarzynski
May 1, 2009·The Journal of Reproduction and Development·Izabela Woclawek-PotockaDariusz J Skarzynski
May 28, 2013·International Journal of Endocrinology·Izabela Wocławek-PotockaDariusz J Skarżyński
Jan 31, 2014·Inflammation·Sabnavis SowmyaAnanthapur Venkateshwari
Nov 12, 2015·American Journal of Reproductive Immunology : AJRI·Julia Szekeres-Bartho
Oct 30, 2007·Best Practice & Research. Clinical Obstetrics & Gynaecology·Katharina T Walch, Johannes C Huber
Apr 7, 2010·American Journal of Reproductive Immunology : AJRI·Julia Szekeres-Bartho, Beata Polgar
Feb 13, 2010·American Journal of Reproductive Immunology : AJRI·Xuan WangShiwu Zhang
Sep 29, 2005·The Journal of Steroid Biochemistry and Molecular Biology·Christian J Gruber, Johannes C Huber
Jul 22, 2015·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Satoru KyoHiroshi Fujiwara
Apr 20, 2014·Mediators of Inflammation·Izabela Wocławek-PotockaDariusz Jan Skarzynski
Feb 20, 2003·American Journal of Obstetrics and Gynecology·Andrea SteinbornHans Grosse-Wilde
Jun 21, 2016·Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology·Susannah S FrenchGregory E Demas
Mar 26, 2003·International Reviews of Immunology·Julia Szekeres-Bartho
Sep 14, 2012·The Journal of Reproduction and Development·Ilona Kowalczyk-ZiebaIzabela Woclawek-Potocka
Jun 22, 1999·American Journal of Reproductive Immunology : AJRI·B PolgarJ Szekeres-Bartho
Mar 20, 2018·Scientific Reports·Eva PallingerJulia Szekeres-Bartho
Jan 9, 2019·Frontiers in Immunology·Julia Szekeres-BarthoBiserka Mulac-Jeričević

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