Early redox imbalance is associated with liver dysfunction at weaning in overfed rats

The Journal of Physiology
E P ConceiçãoP C Lisboa

Abstract

Neonatal overfeeding induced by litter size reduction leads to further obesity and other metabolic disorders, such as liver oxidative stress and microsteatosis at adulthood. We hypothesized that overfeeding causes an early redox imbalance at weaning, which could programme the animals to future liver dysfunction. Thus, we studied lipogenesis, adipogenesis, catecholamine status and oxidative balance in weaned overfed pups. To induce early overfeeding, litters were adjusted to three pups at the 3rd day of lactation (SL group). The control group contained 10 pups per litter until weaning (NL group). Peripheral autonomic nerve function was determined in vivo at 21 days old. Thereafter, pups were killed for further analysis. Differences were considered significant when P < 0.05. The SL pups presented with a higher visceral adipocyte area, higher content of lipogenic enzymes (ACC, FAS) and with a lower content of adipogenic factors (CEBP, PPARγ) in visceral adipose tissue (VAT). Although autonomic nerve activity and adrenal catecholamine production were not significantly altered, catecholamine receptor (β3ADR) content was lower in VAT. The SL pups also presented with higher triglyceride, PPARγ, PPARα and PGC1α contents in liver. In pl...Continue Reading

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Citations

Oct 31, 2015·The Journal of Physiology·You-Lin Tain
Nov 12, 2016·The Journal of Nutritional Biochemistry·Ellen Paula Santos ConceiçãoPatricia Cristina Lisboa
May 12, 2016·Experimental Gerontology·Kallie DavisJames M Harper
Nov 10, 2020·Neuroscience Letters·Pauline Maciel AugustCristiane Matté
May 6, 2021·International Journal of Environmental Research and Public Health·Bernardo Gindri Dos SantosCristiane Matté

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