Early Regenerative Modifications of Human Postmenopausal Atrophic Vaginal Mucosa Following Fractional CO2 Laser Treatment

Open Access Macedonian Journal of Medical Sciences
Stefano SalvatoreNicola Zerbinati

Abstract

Postmenopausal women experience undesired symptoms that adversely affect their quality of life. In the recent years, a specific 12 - week fractional CO2 laser treatment has been introduced, with highly significant relief of symptoms. The aim of this paper is the identification of the early modifications of structural components of atrophic vaginal mucosa induced by laser irradiation, which is responsible for the restorative processes. We investigated by microscopical, ultrastructural and biochemical methods the modifications of the structural components of postmenopausal atrophic vaginal mucosa tissues after 1 hour following a single fractional laser CO2 application. In one hour, the mucosal epithelium thickens, with the maturation of epithelial cells and desquamation at the epithelial surface. In the connective tissue, new papillae indenting the epithelium with newly formed vessels penetrating them, new thin fibrils of collagen III are also formed in a renewed turnover of components due to the increase of metalloproteinase - 2. Specific features of fibroblasts support stimulation of their activity responsible of the renewal of the extracellular matrix, with an increase of mechanical support as connective tissue and stimulation...Continue Reading

Citations

Aug 15, 2019·Climacteric : the Journal of the International Menopause Society·P Cox, N Panay
Nov 13, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·Louise PhotiouHooman Khorasani
Oct 2, 2019·Menopause : the Journal of the North American Menopause Society·Marie Fidela R ParaisoCheryl B Iglesia
Aug 8, 2019·Post Reproductive Health·Santiago PalaciosDanial Khorsandi
Oct 6, 2020·BJOG : an International Journal of Obstetrics and Gynaecology·K MackovaJ Deprest

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biopsies
electron microscopy
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light microscopy
Electrophoresis

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