Early rehabilitation for volumetric muscle loss injury augments endogenous regenerative aspects of muscle strength and oxidative capacity

BMC Musculoskeletal Disorders
Sarah M GreisingJarrod A Call

Abstract

Volumetric muscle loss (VML) injuries occur due to orthopaedic trauma or the surgical removal of skeletal muscle and result in debilitating long-term functional deficits. Current treatment strategies do not promote significant restoration of function; additionally appropriate evidenced-based practice physical therapy paradigms have yet to be established. The objective of this study was to develop and evaluate early rehabilitation paradigms of passive range of motion and electrical stimulation in isolation or combination to understand the genetic and functional response in the tissue remaining after a multi-muscle VML injury. Adult male mice underwent an ~ 20% multi-muscle VML injury to the posterior compartment (gastrocnemius, soleus, and plantaris muscle) unilaterally and were randomized to rehabilitation paradigm twice per week beginning 2 days post-injury or no treatment. The most salient findings of this work are: 1) that the remaining muscle tissue after VML injury was adaptable in terms of improved muscle strength and mitigation of stiffness; but 2) not adaptable to improvements in metabolic capacity. Furthermore, biochemical (i.e., collagen content) and gene (i.e., gene arrays) assays suggest that functional adaptations ...Continue Reading

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Citations

Oct 4, 2019·Tissue Engineering. Part B, Reviews·Sarah M GreisingGordon L Warren
Dec 21, 2019·Tissue Engineering. Part a·Benjamin T CoronaSarah M Greising
Jun 2, 2020·Frontiers in Bioengineering and Biotechnology·Arturo Ibáñez-FonsecaJosé Carlos Rodríguez-Cabello
Oct 9, 2020·Connective Tissue Research·Kayvan Forouhesh TehraniLuke J Mortensen
Feb 5, 2021·Connective Tissue Research·Daniel B HoffmanSarah M Greising
Feb 11, 2021·American Journal of Physiology. Cell Physiology·Anita E QuallsJarrod A Call
Apr 9, 2021·Journal of Applied Physiology·Jacob R SorensenSarah M Greising
Dec 24, 2021·Tissue Engineering. Part a·Brittany Lynn RodriguezLisa Marie Larkin

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Methods Mentioned

BETA
dissection
biopsy
PCR

Software Mentioned

iPathway
JMP

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