PMID: 11902178Mar 21, 2002Paper

Early renal changes in 45 degrees HDT rats

Acta Astronautica
Chris R PettisJack N Hall

Abstract

Both microgravity and simulated microgravity models, such as the 45HDT (45 degrees head-down tilt), cause a redistribution of body fluids indicating a possible adaptive process to the microgravity stressor. Understanding the physiological processes that occur in microgravity is a first step to developing countermeasures to stop its harmful effects, i.e., (edema, motion sickness) during long-term space flights. Because of the kidneys' functional role in the regulation of fluid volume in the body, it plays a key role in the body's adaptation to microgravity. Rats were injected intramuscularly with a radioactive tracer and then lightly anesthetized in order to facilitate their placement in the 45HDT position. They were then placed in the 45HDT position using a specially designed ramp (45HDT group) or prone position (control group) for an experimental time period of 1 h. During this period, the 99mTc-DTPA (technetium-labeled diethylenepentaacetate, MW=492 amu, physical half-life of 6.02 h) radioactive tracer clearance rate was determined by measuring gamma counts per minute. The kidneys were then fixed and sectioned for electron microscopy. A point counting method was used to quantitate intracellular spaces of the kidney proximal t...Continue Reading

References

Jun 24, 1993·The New England Journal of Medicine·J C BuckeyC G Blomqvist
Dec 21, 2000·European Journal of Clinical Investigation·C DrummerM Heer

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Citations

Nov 11, 2003·Acta Astronautica·Christopher Ryan Pettis, Mark Lee Witten

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