Early renal graft function deterioration in recipients with preformed anti-MICA antibodies: partial contribution of complement-dependent cytotoxicity

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Elena Sánchez-ZapardielEstela Paz-Artal

Abstract

We previously reported that preformed anti-MHC class I-related chain A (MICA) antibodies increase the risk for renal graft rejection and enhance the deleterious effect of PRA(+) status early after transplantation. We studied 727 kidney recipients. Days to reach optimal serum creatinine level, estimated glomerular filtration rate (eGFR) at Month 3 and chronic kidney disease (CKD) stages were recorded. Anti-MICA specificities and C1q binding were tested by solid-phase assay. Complement-dependent cytotoxicity (CDC) and flow cytometry (FC) cross-matches with HeLa and PMA/CD28-T-blasts were performed. PRA(+)MICA(+) recipients exhibited longer time to reach optimal serum creatinine level after transplantation (P = 0.005) and had the lowest eGFR at Month 3 (P = 0.006). PRA(+)MICA(+) status independently increased the risk for CKDT stage 5 at Month 3 [hazard ratio (HR) 4.92, P = 0.030]. Pre-transplant anti-MICA antibodies were polyspecific and showed stronger reactions when coexisting with anti-HLA antibodies (mean standard fluorescent intensity 112 157 ± 44 426 in HLA(+)MICA(+) sera versus 49 680 ± 33 116 in HLA(-)MICA(+) sera, P = 0.0006). Anti-AYVE supereplet reactivity was significantly higher in HLA(+)MICA(+) versus HLA(-)MICA(+) ...Continue Reading

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Citations

Jul 11, 2016·Transplantation Reviews·Laura A MichielsenHenny G Otten
Nov 7, 2017·Expert Review of Proteomics·Arjun Chakraborty, Minnie Sarwal
Jan 8, 2017·Journal of the American Society of Nephrology : JASN·Madhav C MenonPeter S Heeger
Sep 25, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Samira FaroukMadhav C Menon
Jun 4, 2016·Current Opinion in Organ Transplantation·Mary Carmelle Philogene, Annette M Jackson
Apr 5, 2017·Journal of Immunology Research·Carrie L ButlerElaine F Reed
Jun 1, 2018·Journal of Immunology Research·Mohit ChowdhryVandana Sharma
Mar 16, 2017·Frontiers in Immunology·Matilde Risti, Maria da Graça Bicalho

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