PMID: 6117171Feb 1, 1981

Early response in central hemodynamics to high doses of sufentanil or morphine in dogs

Acta Anaesthesiologica Scandinavica
J EriksenJ P Rasmussen

Abstract

The hemodynamic effects of high doses of sufentanil, a newly synthetized highly potent analgesic, were investigated in dogs. This study compared the early (30 min) cardiovascular effects of sufentanil 0.01 mg . kg-1 and morphine 4 mg . kg-1. Sufentanil caused a moderate and insignificant decrease in mean arterial pressure (MAP). A 30% decrease in cardiac index (CI) was almost outbalanced by an increased systemic vascular resistance (SVRI). The lowering of CI was due to a more than 50% decrease in heart rate (HR) which was partly compensated for by a greater stroke volume index (SVI). In the first 5 min after morphine injection, MAP fell significantly to about 50 mmHg (below 50% of the control value). CI was reduced to about 50% of the control value because of significant decreases in both SVI and HR. The calculated SVRI was unchanged after morphine. Within 30 min some of the initially changed parameters had returned to control levels. Central venous pressure (CVP) and pulmonary capillary wedge pressure (PCWP) increased immediately after sufentanil, but decreased after morphine. With time, both parameters returned towards control values. Peak left ventricular dP/dt decreased by about 25-50% after both analgesics. The rate-pressu...Continue Reading

References

Jan 1, 1991·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·M M SwindleB A Carabello
May 1, 1994·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·R E SchumannP C Gillette
Aug 19, 2004·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·Ingeborgh PolisMulenda Tshamala
Feb 16, 2006·Veterinary Anaesthesia and Analgesia·Ingeborgh PolisFrank Gasthuys
Feb 1, 1981·Acta Anaesthesiologica Scandinavica·P BerthelsenJ P Rasmussen
Mar 1, 1992·The Veterinary Clinics of North America. Small Animal Practice·D V Wilson
Mar 1, 1992·The Veterinary Clinics of North America. Small Animal Practice·D V Wilson
Oct 1, 1981·Acta Anaesthesiologica Scandinavica·P BerthelsenJ P Rasmussen
Dec 11, 2003·Journal of the American Veterinary Medical Association·Guilherme M Mendes, André L Selmi
Jun 1, 1984·Acta Anaesthesiologica Scandinavica·P BerthelsenJ P Rasmussen

Citations

May 1, 1978·Anaesthesia·A M Florence
Mar 1, 1976·Anesthesia and Analgesia·W LiuJ H Isern-Amaral
Mar 1, 1975·Anesthesiology·G W OstheimerE Lowenstein
Jan 1, 1971·European Journal of Pharmacology·M R Fennessy, J F Rattray
Apr 1, 1971·The American Journal of Cardiology·E Braunwald
Apr 1, 1972·Journal of Applied Physiology·K KitamuraY Wang
Dec 1, 1971·Anesthesiology·E Lowenstein
Dec 18, 1969·The New England Journal of Medicine·E LowensteinM B Laver
Jun 1, 1980·Acta Anaesthesiologica Scandinavica·P BerthelsenJ P Rasmussen
Jan 1, 1964·Toxicology and Applied Pharmacology·J F GARDOCKI, J YELNOSKY
Jan 1, 1964·Toxicology and Applied Pharmacology·J YELNOSKY, J F GARDOCKI

Related Concepts

Dioxygen
Diastolic Blood Pressure
Pulmonary Vascular Resistance
Sufentanil-ratiopharm
Pressure Ulcer
Hemodynamics
Morphine Sulfate (2: 1), Pentahydrate
Oxygen Consumption
Dose-Response Relationship, Drug
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