Early response to tendon fatigue damage accumulation in a novel in vivo model.

Journal of Biomechanics
David T FungEvan L Flatow

Abstract

This study describes the development and application of a novel rat patellar tendon model of mechanical fatigue for investigating the early in vivo response to tendon subfailure injury. Patellar tendons of adult female Sprague-Dawley rats were fatigue loaded between 1-35N using a custom-designed loading apparatus. Patellar tendons were subjected to Low-, Moderate- or High-level fatigue damage, defined by grip-to-grip strain measurement. Molecular response was compared with that of a laceration-repair injury. Histological analyses showed that progression of tendon fatigue involves formation of localized kinked fiber deformations at Low damage, which increased in density with presence of fiber delaminations at Moderate damage, and fiber angulation and discontinuities at High damage levels. RT-PCR analysis performed at 1- and 3-day post-fatigue showed variable changes in type I, III and V collagen mRNA expression at Low and Moderate damage levels, consistent with clinical findings of tendon pathology and were modest compared with those observed at High damage levels, in which expression of all collagens evaluated were increased markedly. In contrast, only type I collagen expression was elevated at the same time points post-lacerat...Continue Reading

References

Jul 1, 1990·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·C BackmanG Toolanen
Jan 1, 1984·Connective Tissue Research·I F WilliamsI A Silver
Jan 1, 1996·Archives of Orthopaedic and Trauma Surgery·K HiranumaH Hirano
Aug 1, 1997·Journal of Biomechanics·H Schechtman, D L Bader
Sep 26, 1997·Journal of Biomechanics·K J Jepsen, D T Davy
Apr 18, 2001·Journal of Shoulder and Elbow Surgery·D H SonnabendW R Walsh
May 3, 2001·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·H SakaiK Saotome
Dec 12, 2001·Medicine and Science in Sports and Exercise·C TallonS W Ewen
Feb 23, 2002·Journal of Biomechanics·H Schechtman, D L Bader
May 25, 2002·Joint, Bone, Spine : Revue Du Rhumatisme·Joaquim Gonçalves-NetoH H Yoshinari
Jun 11, 2003·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·Gordon O Matheson
Jun 12, 2003·Annals of Biomedical Engineering·Tishya A L WrenDennis R Carter
Jun 12, 2003·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·G M ThorntonC B Frank
Sep 26, 2003·The Journal of Hand Surgery·Wataru OshiroPaul R Manske
Oct 17, 2003·Clinics in Sports Medicine·Samir MehtaLouis J Soslowsky
Apr 28, 2004·Journal of Biomechanics·T W Tony W LinL J Louis J Soslowsky
Sep 9, 2004·Medicine and Science in Sports and Exercise·Nicola MaffulliJohn B King
Dec 2, 2004·Sports Medicine·Constantinos N MaganarisNicola Maffulli
Sep 6, 2005·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Leena H NakamaDavid M Rempel
Dec 7, 2006·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Damien LaudierVincent M Wang
Aug 8, 2008·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·David T FungEvan L Flatow

❮ Previous
Next ❯

Citations

May 18, 2013·Bulletin of Mathematical Biology·Mark S Thompson
Jan 10, 2014·Journal of the Royal Society, Interface·Chavaunne T ThorpeHazel R C Screen
Nov 28, 2013·Journal of Biomechanics·Benjamin R FreedmanLouis J Soslowsky
Jul 20, 2012·Annual Review of Biomedical Engineering·Pramod B VoletiLouis J Soslowsky
Feb 18, 2014·Acta Biomaterialia·Spencer E Szczesny, Dawn M Elliott
Nov 2, 2014·Connective Tissue Research·C P VieiraE R Pimentell
Aug 27, 2015·Journal of Cellular Biochemistry·Emmanuel C EkwuemeJoseph W Freeman
Jan 17, 2012·Journal of Shoulder and Elbow Surgery·Andrew NeviaserEvan Flatow
Feb 9, 2016·Interface Focus·Monica E SusiloJeffrey W Ruberti
Mar 13, 2015·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Nelly Andarawis-PuriLouis J Soslowsky
Mar 17, 2015·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Benjamin R FreedmanLouis J Soslowsky
Mar 4, 2015·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·R BellN Andarawis-Puri
Feb 3, 2015·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Hazel R C ScreenMarian F Young
Jan 10, 2012·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Nelly Andarawis-PuriEvan L Flatow
Jul 11, 2013·International Journal of Experimental Pathology·Jennifer H Shepherd, Hazel R C Screen
Aug 3, 2010·Scandinavian Journal of Medicine & Science in Sports·P P Y LuiR K W Smith
May 20, 2014·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Nelly Andarawis-PuriEvan L Flatow
Aug 27, 2014·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Cristiano Pedrozo VieiraEdson Rosa Pimentel
Apr 29, 2015·Scandinavian Journal of Medicine & Science in Sports·S J ObstR S Barrett
Dec 24, 2013·Journal of the Mechanical Behavior of Biomedical Materials·A M ReyesA A Zadpoor
Jun 25, 2014·Bone & Joint Research·M W HastL J Soslowsky
Jul 9, 2014·Journal of the Mechanical Behavior of Biomedical Materials·Jennifer H ShepherdHazel R C Screen
Dec 6, 2014·Current Rheumatology Reports·Julianne HuegelLouis J Soslowsky
Jul 31, 2014·Computer Methods in Biomechanics and Biomedical Engineering·C EngelhardtA Terrier
Jun 14, 2016·Connective Tissue Research·Isaiah AdekanmbiPhilippa Hulley
Apr 29, 2016·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Cristiano Pedrozo VieiraEdson Rosa Pimentel
Sep 30, 2016·PLoS Computational Biology·Stuart R YoungDavid W Smith
Oct 4, 2016·European Journal of Applied Physiology·Thijs Maria Anne AckermansKiros Karamanidis
Apr 22, 2017·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Mark S ThompsonHanna Isaksson
Mar 21, 2018·Connective Tissue Research·Arash MehdizadehDavid W Smith
Sep 4, 2018·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Jared L Zitnay, Jeffrey A Weiss
Sep 4, 2018·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Nelly Andarawis-Puri, Evan L Flatow
Jul 13, 2018·Exercise and Sport Sciences Reviews·W Brent Edwards
Sep 15, 2010·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Hui B SunEvan L Flatow
Oct 3, 2018·American Journal of Physical Medicine & Rehabilitation·Diogo Manuel PortugalCarla V Vera-Cruz
Jun 30, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Eijiro MaedaTakeo Matsumoto
Jan 9, 2020·The American Journal of Sports Medicine·Mikhail GolmanCharles A Popkin
Apr 12, 2019·Medicine and Science in Sports and Exercise·Colin R FirmingerW Brent Edwards

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomechanics

Biomechanics examines the generation of internal forces within the body and investigates the effects and control of forces that act on or are produced on tissues. Here are the latest discoveries.

Related Papers

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
David T FungEvan L Flatow
Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
Hui B SunEvan L Flatow
Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
Nelly Andarawis-PuriEvan L Flatow
© 2022 Meta ULC. All rights reserved