Early results after pediatric cardiac transplantation with triple immunosuppression therapy

The American Journal of Cardiology
C CanterT L Spray

Abstract

Pediatric heart transplant recipients were previously reported to have higher early mortality and morbidity than do adult patients treated with triple immunosuppression therapy (steroids, azathioprine and cyclosporine). Nineteen patients (11 infants and 8 older children) underwent orthotopic transplantation using triple immunosuppression therapy. Surveillance for cellular rejection and coronary arteriopathy was performed with endomyocardial biopsy and selective coronary angiography in all patients, with continuous monitoring for hypertension and serious infection. Seventeen of 19 patients (89%; 10 infants and 7 older children) are current survivors, with a median follow-up of 29 months (range 17 to 94). There were 5 and 7 episodes of rejection in the first 12 months after transplantation in the infant and older groups, respectively, for actuarial freedom-from-rejection rates of 65% at 3 months and 54% at 12 months. Severe coronary arteriopathy was detected in 1 infant 11 months after transplantation. In the first 12 months after transplantation, there were 3 hospitalizations for infection, and 2 patients needed treatment for hypertension in the infant group, compared with 1 hospitalization for infection, and 4 patients on antih...Continue Reading

References

Nov 1, 1989·The Annals of Thoracic Surgery·A TrentoR L Hardesty
Jan 6, 1983·The New England Journal of Medicine·W I NorwoodD D Hansen

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Citations

Aug 26, 1998·Journal of the American College of Cardiology·R L LarsenP M Shah
Mar 14, 2000·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·C L DentD T Balzer
Jul 27, 1999·The Annals of Thoracic Surgery·M J FlippinC E Canter
Jul 28, 2016·The Journal of Thoracic and Cardiovascular Surgery·James S Tweddell

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