Abstract
We evaluated early clinical and radiologic results of core decompression combined with autologous mononuclear bone marrow cell implantation for early stage nontraumatic avascular necrosis of the femoral head. The study included nine patients (1 female, 8 males, mean age 46.5 years; range 33 to 59 years) with stage I-II nontraumatic avascular necrosis of the femoral head, according to the Steinberg classification. Bone marrow-derived CD34 cells were injected through a core decompression channel into the femoral head. Clinical assessment included a visual analog scale (VAS), Harris hip score, and the WOMAC Osteoarthritis Index. Radiologically, femoral head collapse, narrowing of the coxofemoral joint space, and the size of the osteonecrotic area were assessed. The mean follow-up was 27.2 months (range 24 to 38 months). Pre- and postoperative (24th month) evaluations showed that the mean VAS score and the WOMAC Osteoarthritis Index decreased from 3.4+/-0.4 to 1.2+/-0.6, and from 33+/-3 to 11+/-6, respectively, with an increase in the Harris hip score (from 54 to 92). Preoperatively, two patients were Steinberg I-B, four were I-C, and three were II-A. Finally, all the patients were stage 0 except for one patient who regressed to I-...Continue Reading
Citations
Sep 27, 2012·International Orthopaedics·Gwo-Chin Lee, Marvin E Steinberg
Jan 1, 2013·Journal of Materials Science. Materials in Medicine·Qinghua ZhaoZhenkai Wu
Feb 11, 2014·Transplantation Proceedings·J CaiJ Tan
Sep 8, 2010·Biotechnology Progress·Jonathan RidgwayStephen Curran
Mar 29, 2016·Plastic and Reconstructive Surgery·Wenshan XingJie Luan
Oct 7, 2008·Arthritis Research & Therapy·Marcus JägerRüdiger Krauspe
Jul 6, 2005·Theoretical Biology & Medical Modelling·Jacob BejarJochanan H Boss
Oct 29, 2008·BMC Medical Genetics·Tae-Ho KimShin-Yoon Kim
Aug 17, 2011·Osteoarthritis and Cartilage·L H JinB-H Min
Mar 19, 2014·PloS One·Yin-Chih FuMei-Ling Ho
Mar 20, 2015·PloS One·Sheng-Bao ChenChang-Qing Zhang
May 26, 2012·PloS One·Qian WenLi Ma
Nov 10, 2013·PloS One·Li-Zhen ZhengLing Qin
Aug 1, 2006·The Journal of Arthroplasty·Nelson Fong SoohooJay R Lieberman
Apr 2, 2017·Der Orthopäde·Ying ZhangYouwen Liu
Mar 8, 2018·Molecular Medicine Reports·Gang Xu