Abstract
Our goal was to evaluate early results of the clinical application of autologous whole bone marrow stem cell transplantation (AWBMSCT) for critical limb ischemia (CLI) in patients with Buerger's disease. We retrospectively analyzed the data of 58 limbs of 37 patients (mean age, 43.0 years; range, 28-63 years; male, 91.9%) with Buerger's disease with CLI who were treated with AWBMSCT from March 2013 to December 2014. We analyzed Rutherford category, pain score, pain-free walking time (PFWT), total walking time (TWT), ankle brachial pressure index (ABPI), and toe brachial pressure index (TBPI), and investigated wound healing and occurrence of unplanned amputations. The mean follow-up duration was 11.9 ± 7.2 months (range, 0.9-23.9 months) and 100%, 72.4%, and 74.1% of patients were available to follow-up 1, 3 and 6 months after AWBMST, respectively. At 6 months, patients demonstrated significant improvements in Rutherford category (P < 0.0001), pain score (P < 0.0001), PFWT (P < 0.0001) and TBPI (P < 0.0001). ABPI was increased compared to baseline, but the difference was not significant. A total of 76.5% ischemic wounds achieved complete or improved healing. AWBMSCT is a safe and effective alternative or adjunctive treatment mod...Continue Reading
References
Oct 6, 1997·Journal of Vascular Surgery·R B RutherfordD N Jones
Feb 10, 1999·International Journal of Cardiology·S Shionoya
Sep 21, 2002·Lancet·Eriko Tateishi-YuyamaUNKNOWN Therapeutic Angiogenesis using Cell Transplantation (TACT) Study Investigators
Feb 26, 2004·Thrombosis and Haemostasis·Ping Ping HuangZhong Chao Han
Jan 28, 2006·Stem Cells·Dong-Ik KimJong-Sup Shim
Aug 24, 2006·Journal of Vascular Surgery·Serkan DurduUmit Ozyurda
Dec 5, 2006·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·L NorgrenKenneth Rosenfield
Mar 14, 2007·Angiology·Kosmas I ParaskevasDimitri P Mikhailidis
Nov 13, 2008·VASA. Zeitschrift für Gefässkrankheiten·B AmannJ Schmidt-Lucke
Dec 9, 2008·American Heart Journal·Satoaki MatobaUNKNOWN TACT Follow-up Study Investigators
Dec 23, 2008·Journal of Vascular Surgery·Vishnu MotukuruK R Girija
Jun 9, 2009·Cell Transplantation·Berthold AmannJ André Schmidt-Lucke
Jul 19, 2011·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·A-K KimD-I Kim
Oct 25, 2011·Journal of Vascular Surgery·Mark D IafratiSean Roddy
Feb 22, 2013·Annals of Surgery·Martin TeraaMarianne C Verhaar
Dec 4, 2013·Methodist DeBakey Cardiovascular Journal·Crystal M BothamJohn P Cooke
Nov 1, 2011·International Journal of Stem Cells·Kyung-Bok LeeDong-Ik Kim
Aug 5, 2014·Journal of Vascular Surgery·Kristina A GilesRichard J Powell
Aug 26, 2014·VASA. Zeitschrift für Gefässkrankheiten·Peter F Klein-Weigel, Jutta G Richter
Citations
Aug 30, 2018·The Cochrane Database of Systematic Reviews·S Fadilah Abdul WahidNai Ming Lai
Oct 30, 2020·Stem Cell Research & Therapy·Gang FangZhihui Dong
Aug 23, 2020·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·W AkakpoR Yiou