Early rheumatoid arthritis 6 years after diagnosis is still associated with high direct costs and increasing loss of productivity: the Swedish TIRA project

Scandinavian Journal of Rheumatology
E HallertL Bernfort

Abstract

To calculate total costs over 6 years after diagnosis of early rheumatoid arthritis (RA). In the longitudinal prospective multicentre TIRA study, 239 patients from seven units, diagnosed in 1996-98, reported regularly on health-care utilization and the number of days lost from work. Costs were obtained from official databases and calculated using unit costs (Swedish kronor, SEK) from 2001. Indirect costs were calculated using the human capital approach (HCA). Costs were inflation adjusted to Euro June 2012, using the Swedish Consumer Price Index and the exchange rate of June 2012. Statistical analyses were based on linear mixed models (LMMs) for changes over time. The mean total cost per patient was EUR 14,768 in year 1, increasing to EUR 18,438 in year 6. Outpatient visits and hospitalization decreased but costs for surgery increased from EUR 92/patient in year 1 to EUR 444/patient in year 6. Drug costs increased from EUR 429/patient to EUR 2214/patient, mainly because of the introduction of biologics. In year 1, drugs made up for 10% of direct costs, and increased to 49% in year 6. Sick leave decreased during the first years but disability pensions increased, resulting in unchanged indirect costs. Over the following years, di...Continue Reading

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Citations

May 27, 2014·PharmacoEconomics·Till UhligTore K Kvien
Feb 26, 2016·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Alberto MiglioreDavide Integlia
Jan 31, 2015·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Tom AsklöfTimo Pohjolainen
Jul 23, 2016·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Danielle B RiceRobert W Teasell
Nov 1, 2016·Clinical Drug Investigation·Frank R ErnstKevin Vora
Jan 18, 2018·Immunological Investigations·B R SakrZ O Nawito
Aug 30, 2018·Arthritis Care & Research·Michael MouniéNadège Costa
Apr 5, 2020·Annals of the Rheumatic Diseases·Ping-Hsuan HsiehStefan Siebert

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