PMID: 640750Jan 1, 1978Paper

Early rheumatoid-like lesions in rabbits injected with foreign serum: relationship to localization of immune complexes in the lining tissues of joints and cellular content of synovial fluid

International Archives of Allergy and Applied Immunology
A R PooleR R Coombs

Abstract

Immune complex localization in joint tissues and white cell effusion into the joint space as well as synovial lesions are shown to occur in rabbits injected intravenously with bovine serum. Synovial lesions of one knee were found to be associated with immune complexes in joint tissues of the contralateral knee (because of the experimental design very few rabbits had both immunofluorescence and histology performed on the same joint). There was also a week correlation between moderate and gross synovial lesions and cellular effusions of the same joint. Cartilage proteoglycan depletion was seen in some injected animals and this was related to lining cell hyperplasia. Rabbits from different breeding colonies displayed different incidences of lesions suggesting an environmental or genetic influence on the development of rheumatoid-like lesions.

Citations

May 12, 2001·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·F C RobionS Laverty
Mar 15, 2011·Osteoarthritis and Cartilage·V B KrausUNKNOWN OARSI FDA Osteoarthritis Biomarkers Working Group
Jan 1, 1983·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·K KawaiT D Cooke
Jul 1, 1992·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R R Coombs
May 1, 1996·Clinical Orthopaedics and Related Research·S StevensonV M Goldberg

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