Early rise in exhaled nitric oxide and mast cell activation in repeated low-dose allergen challenge

The European Respiratory Journal
E IhreB Dahlén

Abstract

Repeated low-dose allergen inhalation challenge mimics natural allergen exposure, providing a model for early mechanisms in the triggering of asthma. The current authors performed a controlled study to evaluate the time course of changes in exhaled nitric oxide fraction (F(e,NO)) and urinary biomarkers of airway inflammation. Eight subjects with mild allergic asthma completed two 7-day repeated low-dose challenge periods, with diluent and allergen, respectively. Subjects were symptom free at inclusion and were investigated when not exposed to specific allergen. Pulmonary function and symptoms were followed, and F(e,NO) and urinary mediators were correlated to changes in airway responsiveness to histamine and adenosine. Despite no change in pulmonary function (forced expiratory volume in one second mean+/-sem fall 0.3+/-0.7 versus 0.6+/-1.0%, for diluent and allergen, respectively) and no asthma symptoms, repeated allergen exposure, in contrast to diluent, caused significant increases in histamine responsiveness (2.3 doubling doses), an early and gradual increase in F(e,NO) (up to a doubling from baseline) and a small increase in the mast cell marker 9alpha11beta-prostaglandin F(2) after adenosine challenge. In conclusion, seria...Continue Reading

Citations

Jan 28, 2012·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Ewa Maria ŚwiebockaZenon Siergiejko
Sep 19, 2009·Respirology : Official Journal of the Asian Pacific Society of Respirology·Alessandra SandriniDeborah H Yates
Jan 1, 2011·Clinical and Translational Allergy·Avigael H BenhamouPhilippe A Eigenmann
Jun 24, 2008·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·David A KaminskyBarbara Frankowski
Mar 20, 2008·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Richard S HewittD Robin Taylor
Feb 26, 2014·The Journal of Allergy and Clinical Immunology. in Practice·Jörgen SykKjell Alving
Jun 18, 2011·The Clinical Respiratory Journal·Christopher Grainge, Peter Hugo Howarth
Oct 18, 2011·Allergy·R J P van der ValkJ C de Jongste
Sep 13, 2014·British Journal of Clinical Pharmacology·Wha-Yong LeeDave Singh
Oct 15, 2013·The Journal of Allergy and Clinical Immunology·Zuzana DiamantPaul M O'Byrne
Nov 19, 2013·Korean journal of pediatrics·Youn-Soo Hahn

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