Early sensory-perceptual processing deficits for affectively valenced inputs are more pronounced in schizophrenia patients with a history of violence than in their non-violent peers.

Social Cognitive and Affective Neuroscience
Pierfilippo De SanctisM I Krakowski

Abstract

Individuals with schizophrenia are more prone to violent behaviors than the general population. It is increasingly recognized that processing of emotionally valenced stimuli is impaired in schizophrenia, a deficit that may play a role in aggressive behavior. Our goal was to establish whether patients with a history of violence would show more severe deficits in processing emotionally valenced inputs than non-violent patients. Using event-related potentials, we measured how early during processing of emotional valence, evidence of aberrant function was observed. A total of 42 schizophrenia patients (21 with history of violence; 21 without) and 28 healthy controls were tested. Participants performed an inhibitory control task, making speeded responses to pictorial stimuli. Pictures occasionally repeated twice and participants withheld responses to these repeats. Valenced pictures from the International Affective Picture System were presented. Results in controls showed modulations during the earliest phases of sensory processing (<100 ms) for negatively valenced pictures. A cascade of modulations ensued, involving sensory and perceptual processing stages. In contrast, neither schizophrenia group showed early differentiation. Non-...Continue Reading

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Citations

Sep 26, 2013·Social Cognitive and Affective Neuroscience·Satoru IkezawaBruce E Wexler
Jan 29, 2016·Schizophrenia Research·Gábor CsuklyÁdám Szabó
Aug 11, 2015·Psychiatry Research·Menahem I KrakowskiPal Czobor
Jul 23, 2013·Schizophrenia Research·Sarolta KomlósiPál Czobor
May 11, 2016·Translational Psychiatry·G N AndradeJ J Foxe
Jul 26, 2016·Frontiers in Neuroscience·Feng LiuChunshui Yu
Apr 30, 2016·Social Cognitive and Affective Neuroscience·Markus GermarAndreas Mojzisch
Nov 28, 2018·Social Cognitive and Affective Neuroscience·Indrit BèguePatrik Vuilleumier
Oct 15, 2019·International Journal of Psychology : Journal International De Psychologie·Siugmin LayDaniel Valdenegro
Mar 23, 2020·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Pierfilippo De SanctisJohn J Foxe

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