Early short-term treatment with exogenous hydrogen sulfide postpones the transition from prehypertension to hypertension in spontaneously hypertensive rat.

Clinical and Experimental Hypertension : CHE
You-Lin TainPei-Chen Lu

Abstract

ABSTACT Hydrogen sulfide (H2S), nitric oxide (NO), and renin-angiotensin system (RAS) are involved in hypertension. We examined whether early treatment with sodium hydrosulfide (NaHS), an exogenous H2S donor, can regulate H2S-generating pathway, NO pathway, and the RAS, to prevent the transition from prehypertension to hypertension in spontaneously hypertensive rats (SHRs). Four-week-old SHRs and control normotensive Wistar-Kyoto (WKY) rats were assigned into three groups: WKY, SHRs, and SHR + NaHS; SHRs were injected intraperitoneally with sodium hydrosulfide (14 μmol/kg/day) for 4 weeks. SHRs exhibited hypertension at 12 weeks of age, which was blocked by early sodium hydrosulfide administration. Concentrations of H2S were increased in the kidney in SHR + NaHS group versus WKY. Sodium hydrosulfide reduces mRNA expression of four H2S-generating enzymes and decreased 3-mercaptopyruvate sulphurtransferase protein level in SHRs. Early administration of sodium hydrosulfide decreases plasma NG monomethyl-l-arginine (l-NMMA, an inhibitor of NO synthase) level and increases plasma NO level in SHRs. Next, sodium hydrosulfide administration reduces renal mRNA expression of Ren, Atp6ap2, Agt, Ace, and Agtr1a in SHRs. We conclude that ea...Continue Reading

References

Dec 16, 2003·Biochemical and Biophysical Research Communications·Hui YanChaoshu Tang
Oct 14, 2006·Journal of Applied Physiology·Yi Zhun ZhuPhilip K Moore
Jul 20, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Bin GengJunbao Du
Oct 31, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Xia ZhaoJun-Bao DU
Mar 2, 2010·Amino Acids·Hideo Kimura
Apr 3, 2010·Journal of the American Society of Nephrology : JASN·Ming LuJin-Song Bian
Jan 17, 2012·Translational Research : the Journal of Laboratory and Clinical Medicine·Chien-Ning HsuYou-Lin Tain
Mar 22, 2012·Antioxidants & Redox Signaling·Benjamin Lee PredmoreGabriel Gojon
Jul 12, 2012·Nature Reviews. Molecular Cell Biology·Bindu D Paul, Solomon H Snyder
Jul 25, 2013·Frontiers in Endocrinology·Norihiro Shibuya, Hideo Kimura
Sep 12, 2013·Redox Biology·Gopi K KolluruChristopher G Kevil
Aug 8, 2014·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Mohammad R Al-MagablehJoanne L Hart
Dec 3, 2014·Nitric Oxide : Biology and Chemistry·Pauline M SnijderHarry van Goor
Jan 1, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·Shuai YuanChristopher G Kevil
Feb 7, 2015·Nitric Oxide : Biology and Chemistry·Anne M KoningHarry van Goor
Dec 30, 2015·International Journal of Molecular Sciences·You-Lin Tain, Jaap A Joles

❮ Previous
Next ❯

Citations

Jun 15, 2018·Clinical and Experimental Hypertension : CHE·Hiroki MatsuokaAkiko Noda
Jun 10, 2020·American Journal of Physiology. Cell Physiology·Guangdong Yang
May 13, 2018·International Journal of Molecular Sciences·Chien-Ning Hsu, You-Lin Tain
Dec 31, 2019·Oxidative Medicine and Cellular Longevity·Qin Yang, Guo-Wei He
Jan 7, 2021·International Journal of Urology : Official Journal of the Japanese Urological Association·Suo ZouMotoaki Saito
Mar 7, 2021·International Journal of Molecular Sciences·Yi-Zhen WangDong-Dong Wu
Apr 14, 2021·Redox Biology·Maurits RoordaHjalmar R Bouma
Jun 1, 2021·Clinical Hemorheology and Microcirculation·Maria FornalTomasz Grodzicki
Aug 8, 2021·International Journal of Molecular Sciences·Chien-Ning Hsu, You-Lin Tain

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.