Early Signs of Impaired Gut Function Affect Daily Functioning in Patients With Advanced Cancer Undergoing Chemotherapy.

JPEN. Journal of Parenteral and Enteral Nutrition
Barbara S van der MeijM P K J Engelen

Abstract

Gastrointestinal symptoms are common during chemotherapy, but underlying disturbances in gut function and their impact on daily life are unclear. This study investigates gut function in a heterogenous group of cancer patients with gastrointestinal symptoms during chemotherapy and its relation to anabolic response, muscle health, and daily functioning. In 16 patients with solid tumors (mostly stage III+IV) undergoing chemotherapy (T) and 16 healthy (H) matched controls, small-intestinal membrane integrity was measured by urine sugar tests. Protein digestion, absorption, and anabolic response to a conventional protein supplement were analyzed by stable-tracer methods. Muscle mass and strength and daily functioning were assessed. Eighty-one percent of T patients reported gastrointestinal symptoms. Small-intestinal membrane permeability was similar, but active glucose transport was lower in the T group (T, 35.5% ± 3.4% vs H, 48.4% ± 4.7%; P = .03). Protein digestion and absorption tended to be lower in the T group (0.67 ± 0.02 vs 0.80 ± 0.04; P = .08). Net protein anabolic response to feeding was comparable, although lower in cancer patients with recent weight loss. Gut permeability negatively correlated to hand grip strength, glob...Continue Reading

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Nov 28, 2018·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Barbara S van der MeijMariëlle P K J Engelen
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Citations

May 23, 2021·JPEN. Journal of Parenteral and Enteral Nutrition·Sarah K KirschnerMariëlle P K J Engelen
Jun 18, 2021·Current Opinion in Clinical Nutrition and Metabolic Care·Sarah K KirschnerMariëlle P K J Engelen
Jun 23, 2021·Current Opinion in Clinical Nutrition and Metabolic Care·Ingeborg M DekkerNicolette J Wierdsma

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