Early signs of neuronal apoptosis in the substantia nigra pars compacta of the progressive neurodegenerative mouse 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid model of Parkinson's disease

Neuroscience
L NovikovaY S Lau

Abstract

Parkinson's disease is associated with a progressive loss of substantia nigra pars compacta dopaminergic neurons. The cellular and molecular mechanisms underlying Parkinson's disease neurodegeneration have not been fully determined. Clinical investigations and subacute in vivo studies using the neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine have generated some observations suggesting that apoptosis is involved in neurodegeneration; however, this view remains equivocal. In this study, the substantia nigra pars compacta neurodegenerative process was examined in the chronic mouse 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid model of Parkinson's disease treated with 10 doses of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (25 mg/kg) and probenecid (250 mg/kg) over five weeks. One day after chronic treatment, numerous terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling-positive cells were detected specifically in the substantia nigra pars compacta displaying shrunken volume, chromatin condensation, and DNA fragmentation. The number of apoptotic cells declined over time. No terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling-positive cells were found in untreated ...Continue Reading

References

Nov 1, 1992·The Journal of Cell Biology·Y GavrieliS A Ben-Sasson
Jun 1, 1995·Neurodegeneration : a Journal for Neurodegenerative Disorders, Neuroprotection, and Neuroregeneration·B S JeonR E Burke
Sep 1, 1995·Neurobiology of Aging·I R MackenzieD G Munoz
Feb 3, 1997·The Journal of Comparative Neurology·C Portera-CailliauL J Martin
Apr 2, 1998·Experimental Cell Research·M Leist, P Nicotera
Apr 11, 2001·Movement Disorders : Official Journal of the Movement Disorder Society·H TurmelE C Hirsch
Aug 31, 2001·Microscopy Research and Technique·P J Gebicke-Haerter
Jan 5, 2002·Mental Retardation and Developmental Disabilities Research Reviews·K A Roth, C D'Sa
Aug 30, 2002·Neurotoxicology and Teratology·A Nicotra, S Parvez
Oct 16, 2002·Glia·Uwe-Karsten Hanisch
Jan 7, 2004·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Bryan L Garris, David R Garris

❮ Previous
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Citations

May 14, 2011·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Min-Jeong LeeHyung Soo Han
Jun 16, 2009·Neurotoxicity Research·Nicoletta SchintuAnna R Carta
Mar 20, 2010·Neurotoxicity Research·Trevor Archer, Anders Fredriksson
Aug 11, 2011·Neurotoxicity Research·Trevor Archer, Anders Fredriksson
Feb 10, 2012·PLoS Genetics·Erin K ButlerJörg B Schulz
Jun 15, 2007·Expert Review of Neurotherapeutics·Ennio EspositoGiuseppe Di Giovanni
Jun 18, 2010·Neurobiology of Disease·Jian-Hua ZhangMichael H Chase
Aug 18, 2009·Neuroscience Letters·Jason R Cannon, J Timothy Greenamyre
Dec 7, 2007·Journal of the Neurological Sciences·Carla BattistiAntonio Federico
Nov 6, 2007·Neuroscience Letters·Max J KurzYuen-Sum Lau
Mar 6, 2007·Medical Hypotheses·Joëlle AlcockVirginie Sottile
Apr 17, 2007·Experimental Neurology·Ennio EspositoGiuseppe Di Giovanni
Apr 6, 2007·Brain Research Reviews·Sarika Singh, Madhu Dikshit
Feb 28, 2009·The European Journal of Neuroscience·Nicoletta SchintuAnna R Carta
Sep 3, 2008·Journal of Neurochemistry·Daniel Alvarez-FischerPatrick P Michel
Apr 14, 2011·British Journal of Pharmacology·Susan Duty, Peter Jenner
Apr 9, 2016·Neuroscience Letters·Cynthia A Kelm-NelsonMichelle R Ciucci
Jul 12, 2011·Pharmacology, Biochemistry, and Behavior·Gaurav Patki, Yuen-Sum Lau
Nov 18, 2008·Neuroscience Letters·Vasutakarn ChongthammakunSukumal Chongthammakun
Oct 23, 2012·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Stéphanie PainSylvie Chalon
Dec 12, 2012·Neurochemistry International·Claudia FunkeDouglas B Kell
Oct 13, 2010·Biochemical and Biophysical Research Communications·Marina YamadaMasao Kaneki
Feb 15, 2015·Molecular Neurobiology·Wei DuanQing Yin
Jun 22, 2018·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·Yu S MironovaA V Latypova
Aug 14, 2009·Expert Review of Neurotherapeutics·Makoto Naoi, Wakako Maruyama
Jun 22, 2007·The Journal of Biological Chemistry·Mathieu MarellaTakao Yagi

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