Early single dose therapy with ofloxacin for empirical treatment of acute gastroenteritis: a randomised, placebo-controlled double-blind clinical trial

The Journal of Antimicrobial Chemotherapy
A NogueradoR Gabriel

Abstract

This study is a double-blind, placebo-controlled, randomised clinical trial to evaluate the clinical and microbiological efficacy and safety of single dose ofloxacin for acute diarrhoea. Eligible patients were 16 years of age or older with a history of acute diarrhoea lasting no more than 48 h; 117 patients were randomised and 97.4% (114/117) were evaluable for efficacy. Of these, 58% were suspected to have ingested contaminated foods. Enteric pathogens were isolated in 61.5% of the patients, Salmonella enteritidis being reported in 87.5%. The patients received either a single 400 mg dose of ofloxacin, or placebo. The average duration of diarrhoea was 2.56 +/- 2.21 days in the ofloxacin group and 3.41 +/- 2.5 in the placebo group (P = 0.117). The average duration of fever was 0.63 +/- 0.95 days in the ofloxacin group and 1.05 +/- 0.96 in the placebo group (P = 0.02). Symptoms remained unchanged for more than 48 h in only 7% of the patients who received ofloxacin, compared with 12% in the placebo group (P = 0.485). Only 32% of patients in the ofloxacin group remained culture positive after 48 h compared with 59% in the placebo group (P = 0.0018). These represent a relative risk reduction (RRR) for stool clearance of 45.5% and ab...Continue Reading

Citations

Mar 25, 2000·Veterinary Microbiology·E van Duijkeren, D J Houwers
Nov 17, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David R HillUNKNOWN Infectious Diseases Society of America
Jun 16, 2000·The Western Journal of Medicine·G de Bruyn
May 22, 2009·Gastroenterology·Lori R HoltzPhillip I Tarr
Apr 7, 2010·Journal of Evaluation in Clinical Practice·Stephen Ayre, Gareth Walters
Dec 13, 2003·Journal of Health Psychology·Sally D ParryMark R Welfare
Jul 15, 2003·American Journal of Veterinary Research·Marie-Eve FecteauBradford P Smith
Nov 16, 2012·The Cochrane Database of Systematic Reviews·Ifeanyi A OnwuezobeChibuzo C Odigwe
Jun 27, 2000·Gastroenterology·S Banerjee, J T LaMont

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