Early social deprivation induces disturbed social communication and violent aggression in adulthood

Behavioral Neuroscience
Mate TothJózsef Haller

Abstract

Disturbed social relations during childhood (e.g., social neglect) often lead to aggression-related psychopathologies in adulthood. Social isolation also increased aggressiveness in laboratory animals. Here the authors show in rats, that social isolation from weaning not only increases the level of aggressiveness, but results in abnormal attack patterns and deficits in social communication. In socially deprived rats, the share of attacks aimed at vulnerable body parts of opponents (head, throat, and belly) dramatically increased and the attack/threat ratio was shifted toward attacks, suggesting a decrease in intention signaling. Moreover, a Multiple Regression Analysis showed that the nonassociation of attacks with offensive threats predicted the occurrence of vulnerable attacks with 81.1% accuracy. The authors suggest that the social deprivation-induced abnormal aggression models the aggression-related problems resulting from early social neglect in humans, and studies on its brain mechanisms may increase our understanding of the mechanisms underlying psychopathologies resulting from early social problems.

Citations

Apr 23, 2013·Cell and Tissue Research·Laura M HuckinsGabriela Sánchez-Andrade
Apr 6, 2012·PloS One·Anastasia DiamantopoulouFotini Stylianopoulou
Dec 19, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Thomas Adams, J Amiel Rosenkranz
May 3, 2012·Behavioural Brain Research·Mate TothJozsef Haller
Jul 20, 2011·Behavioural Brain Research·Cristiane Felisbino SilvaCilene Lino de Oliveira
Apr 22, 2015·Nature Reviews. Neuroscience·Carmen Sandi, József Haller
Jun 13, 2015·Royal Society Open Science·Saskia HesseTimo Thünken
Oct 7, 2010·The International Journal of Neuropsychopharmacology·Erica ZamberlettiDaniela Parolaro
May 31, 2016·Neuroscience and Biobehavioral Reviews·Jozsef Haller
Sep 14, 2016·Behavioural Brain Research·Sharon S LanderInna Gaisler-Salomon
Jul 8, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Éva MikicsNina N Karpova
Aug 18, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sam A Golden, Aki Takahashi
May 29, 2018·Psychiatry and Clinical Neurosciences·Juzoh UmemoriEero Castrén
Sep 23, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Meghan E Flanigan, Scott J Russo
Mar 22, 2019·Scientific Reports·Jiří PatokaLuděk Bartoš
Dec 11, 2019·Translational Psychiatry·Nichola M BrydgesJeremy Hall
Aug 23, 2020·International Journal of Molecular Sciences·Aroa Mañas-OjedaEsther Castillo-Gómez
May 28, 2021·Neurobiology of Stress·Chih-Hua ChangPo-Wu Gean

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