Early social environment interferes with the development of NADPH-diaphorase-reactive neurons in the rodent orbital prefrontal cortex

Journal of Neurobiology
G PoeggelK Braun

Abstract

The influence of early parental deprivation on the development of NADPH-diaphorase-(NO-synthase) reactive neuron numbers in subregions of the orbital prefrontal cortex (ventrolateral orbital, lateral orbital, and agranular insular cortex) was quantitatively investigated in the precocious lagomorph Octodon degus. Forty-five-day-old degus from three groups were compared: (1) repeated parental separation: degus that were repeatedly separated from their parents during the first three postnatal weeks and thereafter raised in undisturbed social conditions; (2) chronic isolation: degus that were raised under undisturbed social conditions until postnatal day 21, and then were reared in chronic social isolation; and (3) control: degus that were reared undisturbed in their families. Compared to the control animals the ventrolateral orbital prefrontal cortex and agranular insular cortex of the two deprived groups displayed significantly decreased density of NADPH-diaphorase-reactive neurons (down to 62% in the ventrolateral orbital prefrontal cortex of males, 70% in the agranular insular cortex, and in the lateral orbital prefrontal cortex 80% in both genders). These results confirm that early changes of social environment interferes with...Continue Reading

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Citations

Mar 17, 2007·The International Journal of Neuroscience·Rodrigo PascualAntoni Valero-Cabré
Apr 14, 2010·Behavioural Brain Research·Natalija PopovićMiroljub Popović
Jul 19, 2012·The European Journal of Neuroscience·Daniel L HummerTheresa M Lee
Mar 15, 2011·Developmental Psychobiology·Valentina ColonnelloJaak Panksepp
Oct 11, 2005·Neurobiology of Aging·Burton SingerCarol D Ryff
Aug 19, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Daniel L HummerTheresa M Lee
May 18, 2021·Frontiers in Neuroanatomy·Thomas van GroenMiroljub Popović

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