Early social isolation augments alcohol consumption in rats

Behavioural Pharmacology
Heidi M B LesscherLouk J M J Vanderschuren

Abstract

There is a considerable degree of individual vulnerability for alcohol use disorder (AUD) as only a subpopulation of individuals who regularly consume alcohol develop AUD. It is therefore very important to understand the factors and mechanisms that contribute towards the individual risk for AUD. In this respect, social influences, in particular during development, may be relevant for AUD as disruptions in early social experiences are associated with an increased risk for AUD. Social play, the most prominent form of social behaviour shown by young mammals, is rewarding and considered to be important for social, emotional and cognitive development. Recent studies suggest that early social isolation, effectively depriving animals from social play, increases the risk for addictive behaviour. The aim of this study was therefore to explore the long-term consequences of early social isolation on alcohol consumption and motivation for alcohol. To this end, rats were socially isolated from postnatal days 21-42, followed by 4 weeks of social housing, and voluntary alcohol consumption and operant responding for alcohol were determined in adulthood. We observed enhanced levels of alcohol consumption in adulthood in previously isolated rats...Continue Reading

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Citations

Oct 21, 2015·Genes, Brain, and Behavior·D BelinJ W Dalley
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Oct 22, 2016·Neuroscience and Biobehavioral Reviews·Louk J M J VanderschurenViviana Trezza
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Jan 24, 2020·Neuroscience and Biobehavioral Reviews·Janna M ColaizziMartin P Paulus
Aug 3, 2021·Psychopharmacology·Heidi M B LesscherLouk J M J Vanderschuren

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