Early-stage atherosclerosis in poloxamer 407-induced hyperlipidemic mice: pathological features and changes in the lipid composition of serum lipoprotein fractions and subfractions

Lipids in Health and Disease
T A KorolenkoNatalia A Zhukova

Abstract

The aims of this study were to evaluate the effect of poloxamer 407 administration on atherogenic serum lipoprotein fractions and subfractions associated with cholesterol, triglycerides and phospholipids, as well as the onset of early atherosclerosis, in mice. Mice were administered either sterile saline or poloxamer 407 (to induce a dose-controlled hyperlipidemia) for 1 month and then sacrificed at 1, 4 and 10 days after the last dose of poloxamer 407. Systolic and diastolic blood pressure, the activity of a cysteine protease (cathepsin B) in cardiac and liver tissue, and histological/morphological examination of heart and liver specimens was performed for each group of mice at each time point. Lastly, small angle X-ray scattering was utilized to analyze the lipoprotein fractions and subfractions associated with cholesterol, triglycerides and phospholipids for both groups of mice at each time point. Statistical analysis was performed using one-way, analysis-of-variance with post hoc analysis to determine significantly different mean values, while correlation analysis employed the Spearman test. Poloxamer 407-treated mice revealed significant hyperlipidemia, moderately elevated blood pressure, general lipidosis in liver cells, ...Continue Reading

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Citations

Apr 17, 2018·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Unji LeeHee Eun Kang
Aug 5, 2017·Journal of Cardiovascular Pharmacology·Thomas P JohnstonAmirhossein Sahebkar
Apr 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tatiana A KorolenkoVaclav Vetvicka
Sep 7, 2017·Scientific Reports·Susana Suárez-GarcíaLluís Arola
Oct 15, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·Umur KelesMehmet Ozturk
Oct 28, 2017·International Journal of Biological Macromolecules·T A KorolenkoO L Karmatskikh

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Methods Mentioned

BETA
X-ray
light microscopy

Software Mentioned

STATISTICA

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