Abstract
The aims of this study were to evaluate the effect of poloxamer 407 administration on atherogenic serum lipoprotein fractions and subfractions associated with cholesterol, triglycerides and phospholipids, as well as the onset of early atherosclerosis, in mice. Mice were administered either sterile saline or poloxamer 407 (to induce a dose-controlled hyperlipidemia) for 1 month and then sacrificed at 1, 4 and 10 days after the last dose of poloxamer 407. Systolic and diastolic blood pressure, the activity of a cysteine protease (cathepsin B) in cardiac and liver tissue, and histological/morphological examination of heart and liver specimens was performed for each group of mice at each time point. Lastly, small angle X-ray scattering was utilized to analyze the lipoprotein fractions and subfractions associated with cholesterol, triglycerides and phospholipids for both groups of mice at each time point. Statistical analysis was performed using one-way, analysis-of-variance with post hoc analysis to determine significantly different mean values, while correlation analysis employed the Spearman test. Poloxamer 407-treated mice revealed significant hyperlipidemia, moderately elevated blood pressure, general lipidosis in liver cells, ...Continue Reading
References
Jan 1, 1981·Methods in Enzymology·A J Barrett, H Kirschke
Dec 1, 1994·Current Opinion in Lipidology·M A AustinJ D Brunzell
Oct 1, 1996·Circulation·K JuulB G Nordestgaard
Apr 17, 1998·Atherosclerosis·W K PalmerT P Johnston
Mar 24, 2000·Atherosclerosis·T P JohnstonE E Emeson
Feb 28, 2002·Journal of Cardiovascular Pharmacology·Thomas P JohnstonOssama Tawfik
Oct 15, 2003·The Journal of Clinical Endocrinology and Metabolism·Frank M Sacks, Hannia Campos
Apr 16, 2004·Journal of Cardiovascular Pharmacology·Thomas P Johnston
Apr 7, 2006·Handbook of Experimental Pharmacology·P CullenS Lorkowski
Sep 20, 2006·Chemistry and Physics of Lipids·Jiong-Wei WangGuo-Jiang Zhang
Jan 17, 2007·Circulation·Elena AikawaRalph Weissleder
Apr 18, 2007·Journal of Cardiovascular Pharmacology·Thomas P Johnston, Xinghua Zhou
Jan 12, 2008·Autophagy·Daniel J KlionskyRussell L Deter
Dec 27, 2008·Biochimica Et Biophysica Acta·Dong DengGuo-jiang Zhang
May 6, 2009·Circulation·H Robert Superko
Jun 10, 2010·Current Opinion in Lipidology·Ronald M Krauss
Nov 9, 2010·The Journal of Pharmacy and Pharmacology·Thomas P Johnston
Jan 29, 2011·Lipids in Health and Disease·Guiyuan JiZhuoqin Jiang
Mar 16, 2011·Journal of Biomedicine & Biotechnology·Carlos ZaragozaJesus Egido
Mar 23, 2011·Trends in Endocrinology and Metabolism : TEM·Hanqing Dong, Mark J Czaja
May 19, 2011·The Journal of Pharmacy and Pharmacology·Tatyana A KorolenkoVassilij I Kaledin
Mar 15, 2012·Journal of Lipid Research·M P AdorniT Sampietro
Nov 28, 2012·Canadian Journal of Physiology and Pharmacology·Tatyana A KorolenkoAnna A Monoszon
Mar 13, 2013·Experimental Biology and Medicine·Mariarosaria NapolitanoElena Bravo
Jun 21, 2013·Clinica Chimica Acta; International Journal of Clinical Chemistry·Xiao-Hua YuChao-Ke Tang
Jan 24, 2014·PloS One·Zhenghui Gordon JiangYusuke Tsugawa
Feb 5, 2014·Journal of Lipid Research·Chad M TrentIra J Goldberg
Mar 26, 2014·Journal of the American Heart Association·Abhijeet DhobleStephen L Kopecky
May 21, 2014·Heart·Christopher LabosGeorge Thanassoulis
Dec 3, 2014·Biochimica Et Biophysica Acta·Yang ChenPin-Lan Li
Citations
Oct 25, 2016·International Journal of Pharmaceutics·Emmanuel Omari-SiawJiangnan Yu
Apr 17, 2018·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Unji LeeHee Eun Kang
Aug 5, 2017·Journal of Cardiovascular Pharmacology·Thomas P JohnstonAmirhossein Sahebkar
Aug 31, 2017·Scientific Reports·Shi-Jie ZhangQi Wang
Jun 4, 2018·Neurochemical Research·Christa L MontgomeryPeter Koulen
Aug 21, 2019·Food Science & Nutrition·Wenwen DengXiming Xu
Apr 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tatiana A KorolenkoVaclav Vetvicka
Sep 7, 2017·Scientific Reports·Susana Suárez-GarcíaLluís Arola
Oct 15, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·Umur KelesMehmet Ozturk
Oct 28, 2017·International Journal of Biological Macromolecules·T A KorolenkoO L Karmatskikh