PMID: 3756776Nov 15, 1986Paper

Early stage head and neck non-Hodgkin's lymphoma. The effect of tumor burden on prognosis

Cancer
H ShiratoG Irie

Abstract

Treatment results were investigated in 113 previously untreated patients with clinical Stage I and II (Ann Arbor) non-Hodgkin's lymphoma of the head and neck. Fifty-six Waldeyer's ring, 34 other extranodal sites, and 23 cervical nodal lesions were included. The overall relapse-free survival at 5 years was 41%. Age and Ann Arbor stage influenced relapse-free survival. The results suggested that the tumor cell burden is a fundamental prognostic factor for patients with Waldeyer's ring disease and for patients with only cervical nodal disease. Abdominal relapse was most frequent, followed by generalized relapse. From 1981, patients were randomized in a clinical trial to receive either chemotherapy (cyclophosphamide, vincristine, and prednisone [CVP], five courses) or whole-abdominal irradiation (25 Gy/20 Fr) as an adjuvant therapy. Patients could not tolerate the whole-abdominal irradiation well. A significant improvement in survival has been obtained by adjuvant chemotherapy.

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Citations

Sep 1, 1994·European Journal of Cancer. Part B, Oral Oncology·A AvilésA Rosas
Mar 29, 2002·Survey of Ophthalmology·Russell W ReadNarsing A Rao
Oct 26, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R A PopescuM E Hill
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Jul 13, 2007·International Journal of Pediatric Otorhinolaryngology·Jong-Lyel RohHyung Nam Moon
Jan 1, 1992·Critical Reviews in Oncology/hematology·M R MirzaL Specht

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