Early-stage Neuroendocrine Carcinoma of the Esophagus Observed with Annual Endoscopy for Three Years

Internal Medicine
Yasuyuki TanakaShinsuke Shibuya

Abstract

An 80-year-old man was found to have a reddish depressed lesion on the middle thoracic esophagus. The morphology of the lesion had been almost unchanged for 3 years, but it transformed to a 2-cm depressed lesion with elevated margins and an irregular nodular surface. The lesion was resected endoscopically and ultimately diagnosed as a combined neuroendocrine carcinoma and squamous cell carcinoma with submucosal invasion. The patient was additionally treated with chemoradiotherapy but died of the primary disease eight months after the initial treatment. It is important to elucidate the natural history of this disease at an early stage.

References

Feb 24, 1999·Human Pathology·K TakuboK Sasajima
Aug 2, 2008·The American Journal of Surgical Pathology·Dipen M MaruWayne L Hofstetter
Mar 19, 2019·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·J OgumaG Ogura

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Methods Mentioned

BETA
biopsy
surgical resection
dissection

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Carcinoma, Squamous Cell

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